Results 141 to 150 of about 1,893,519 (318)

Optimization, Production, Purification of Laccase Enzyme from Bacillus sp [PDF]

, 2020
Nivedharshini Tamilvanan
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Microbial and enzymatic biodegradation of aflatoxins and ochratoxins: mechanisms, applications, and emerging innovations. [PDF]

Arch Microbiol
Aasa AO, Govender SE, Malgas S, Thantsha MS.   +3 more
europepmc   +1 more source

ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism

, 2020
Atsuko Nagaoka, Yasuto Kunii, Mizuki Hino, Ryuta Izumi, Chisato Nagashima, Akari Takeshima, Makoto Sainouchi, Hiroyuki Nawa, Akiyoshi Kakita, Hirooki Yabe   +9 more
openalex   +1 more source

Association Between Posttraumatic Stress Disorder Following Myocardial Infarction and Liver Enzyme Levels: A Prospective Study [PDF]

, 2009
Roland von Känel, Chiara Abbas, Stefan Begré, Marie‐Louise Gander, Hugo Saner, Jean‐Paul Schmid   +5 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Efficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions. [PDF]

Glycobiology
de Ram C, Berkhout MD, Kozioł M, Blasco Matias L, Klostermann C, Pandeirada CO, Boeren S, Ioannou A, Vincken JP, Belzer C, Schols H.   +10 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enzyme therapy as a promising strategy to overcome multi-drug resistance in pathogens: current advances, key challenges, and future directions. [PDF]

RSC Adv
Saini S, Yadav R, Das R, Singh C.
europepmc   +1 more source

EFFECT OF NEEM AND WILLOW AQUEOUS EXTRACTS ON FUSARIUM WILT DISEASE IN TOMATO SEEDLINGS: 1-INDUCTION OF ANTIOXIDANT DEFENSIVE ENZYMES [PDF]

, 2011
R.M Farag Hanaa, Abdou Zeinab A., Salama Dawlat A., Ibrahim Mervat A.R., Sror H.A.M.   +4 more
openalex   +1 more source