Results 141 to 150 of about 3,216,786 (362)

Spatial activity mapping of ß-mannanase on soybean seeds

Scientific Reports
For farm animals the supplementation of exogenous enzymes, like ß-mannanase, to soybean-based diets is beneficial to improve feed digestibility. In order to unravel the effect of ß-mannanase on soybean meal’s cell structure, a novel imaging concept was ...
Markus Rueckel, Sven Janson, Arne Solbak, Anna Fickler   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effect of the C-terminal Non-catalytic Domain on the Enzymatic Properties of Thermophilic α-Glucan Phosphorylase TsGP

Shipin gongye ke-ji
In order to obtain α-glucan phosphorylase with good heterologous expression level and enzymatic properties and to investigate the impact of structural domains on the enzyme, a novel α-glucan phosphorylase TsGP was screened from the hyperthermophilic ...
Yali CHEN, Qian WANG, Han LIU, Zhiyou ZONG, Shuli MAN, Yuanxia SUN, Peng CHEN   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules [PDF]

, 2019
Yin–Wei Kuo, Olivier Trottier, Mohammed Mahamdeh, Jonathon Howard   +3 more
openalex   +1 more source

A Customized Bayesian Algorithm to Optimize Enzyme-Catalyzed Reactions

, 2023
Ryo Tachibana, Kailin Zhang, Zhi Zou, Simon Burgener, Thomas R. Ward   +4 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

High-mobility group protein B1 (HMGB1) level in plasma of alcohol use disorder patients in withdrawal state

Middle East Current Psychiatry
Background Alcohol use disorder (AUD) and alcohol withdrawal syndrome (AWS) are known to be accompanied by inflammatory processes caused by the toxic effects of alcohol and cell death.
Anna S. Tolmacheva, Daria V. Bobrik, Mark M. Melamud, Ilia S. Efremov, Georgy A. Nevinsky, Valentina N. Buneva, Elvina A. Akhmetova, Azat R. Asadullin, Evgeny A. Ermakov   +8 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Arginase: an old enzyme with new tricks

, 2015
Ruth B. Caldwell, Haroldo A. Toque, S. Priya Narayanan, R. William Caldwell   +3 more
openalex   +1 more source