Results 181 to 190 of about 1,893,519 (318)

Special Issue "Targeting of Functional Proteins in Disease Therapeutics: Enzyme Function and Inhibition Studies". [PDF]

Int J Mol Sci
Kim SK.
europepmc   +1 more source

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes

, 2005
Shaukath Ara Khanum, Satish Kumar Murari, Bannikuppe Sannanaik Vishwanth, S. Shashikanth   +3 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

The Roles of Enzymes as Dietary Additives in Ruminant Diets: A Meta-Analysis. [PDF]

Animals (Basel)
Ramdani D, Rahmatillah RS, Yanza YR, Jayanegara A, Wathoni N, Chaudhry AS.   +5 more
europepmc   +1 more source

Top‐down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms

Francis Berthias, Nurgül Bilgin, Jasmin Mecinović, Ole N. Jensen   +3 more
openalex   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

P450 Cyptide Synthase KwwB Catalyzes Trp-C5-Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides. [PDF]

Org Lett
Haedar JR, Kumari GS, Kiselov V, Romanuks V, Smits G, Donadio S, Phan CS.   +6 more
europepmc   +1 more source

Detection of DT‐diaphorase Enzyme with a ParaCEST MRI Contrast Agent

, 2017
Iman Daryaei, Kyle M. Jones, Mark D. Pagel   +2 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily. [PDF]

Angew Chem Int Ed Engl
Drexler L, F Fürtges T, Rudack T, Sterner R.   +3 more
europepmc   +1 more source