Results 81 to 90 of about 186,812 (342)

Eosinophils in glioblastoma biology

Journal of Neuroinflammation, 2012
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The development of this malignant glial lesion involves a multi-faceted process that results in a loss of genetic or epigenetic gene control, un-regulated cell growth, and ...
Curran Colleen S, Bertics Paul J
doaj   +1 more source

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Mechanisms involved in human eosinophil chemotaxis induced by the newly cloned C-C chemokine eotaxin

Allergology International, 1998
The present study was performed in order to investigate the mechanism(s) involved in eotaxin-induced normal human eosinophil chemotaxis using a 48-well micro-chemotaxis chamber assay.
Amr El-Shazly, Keisuke Masuyama, Masao Eura, Takeru Ishikawa   +3 more
doaj   +1 more source

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

Gut, 2014
Objective Eosinophils reside in the colonic mucosa and increase significantly during disease. Although a number of studies have suggested that eosinophils contribute to the pathogenesis of GI inflammation, the expanding scope of eosinophil-mediated ...
J. Masterson, E. McNamee, S. Fillon, L. Hosford, Rachel F. Harris, Shahan D. Fernando, P. Jedlicka, R. Iwamoto, E. Jacobsen, C. Protheroe, H. Eltzschig, S. Colgan, M. Arita, James J. Lee, G. Furuta   +14 more
semanticscholar   +1 more source

Eosinophilic arthritis [PDF]

Rheumatology, 1999
To report the clinical picture, laboratory findings and management of 10 patients presenting with acute polyarthritis and hypereosinophilia of unknown causation.Patients presenting with acute arthritis and elevated eosinophil counts (>0.7x10(9) cells/l) or percentage (>11%) were studied during the period 1990-1997.
openaire   +2 more sources

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Genome‐wide association study and polygenic risk scores of eosinophilia in Taiwan

Clinical & Translational Immunology
Objectives Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examining polygenic risk scores (PRS ...
Hsing‐Fang Lu, Su Boon‐Yong, Chi‐Ya Yang, Jiu‐Yao Wang, Yen‐Ting Chang, Fuu‐Jen Tsai   +5 more
doaj   +1 more source

Benralizumab Completely Depletes Gastrointestinal Tissue Eosinophils and Improves Symptoms in Eosinophilic Gastrointestinal Disease

, 2022
Fei Li Kuang, Michelly Sampaio De Melo, Michelle Makiya, Sheila Kumar, Thomas Brown, Lauren Wetzler, JeanAnne Ware, Paneez Khoury, Margaret H. Collins, Martha Quezado, Stefania Pittaluga, Amy D. Klion   +11 more
openalex   +2 more sources

Targeting the IL-5 pathway in eosinophilic asthma: a comparison of mepolizumab to benralizumab in the reduction of peripheral eosinophil counts [PDF]

, 2021
Arian Ghassemian, Jane Jiyoon Park, Michael Tsoulis, Harold Kim   +3 more
openalex   +1 more source

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation

Journal of Experimental Medicine, 1994
Eosinophil accumulation is a prominent feature of allergic inflammatory reactions, such as those occurring in the lung of the allergic asthmatic, but the endogenous chemoattractants involved have not been identified.
Airways Inflammation, P. Jose, D. Grif, P. Collins, D. Walsh, R. Moqbel, N. Totty, O. Truong, J. Hsuan, Timothy Williams   +9 more
semanticscholar   +1 more source