Results 91 to 100 of about 9,401 (207)

Certified reference material against PR3 ANCA IgG autoantibodies. From development to certification. [PDF]

, 2018
Background The importance of the standardisation of immunoassays for autoantibodies has been widely discussed. The appropriate use of certified reference materials (CRM) could contribute to a more accurate diagnosis and follow-up of a series of diseases ...
Committee for the Harmonisation of Autoimmune Testing (C-HAT) of, Hutu, DP, Meroni, PL, Monogioudi, E, Schimmel, H, Sheldon, J, Zegers, I   +6 more
core   +1 more source

Detection of Diagnostic Antibodies in Immune‐Mediated Diseases: A Focus on Antigens and Technologies

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review explores autoantibody detection in immune‐mediated diseases, highlighting autoantigens including post‐translational modifications. We compared enzyme‐linked immunosorbent assay and indirect immunofluorescence with automated chemiluminescence platforms.
Silvia Bracci, Feliciana Real‐Fernandez, Federico Pratesi, Francesca Nuti, Paolo Rovero, Anna Maria Papini   +5 more
wiley   +1 more source

Eosinophilic Granulomatosis with Polyangiitis (EGPA): A Case Report Presenting with Peripheral Polyneuropathy

Journal of Clinical Rheumatology and Immunology
Background: Eosinophilic granulomatosis with polyangiitis is a rare clinical condition with multiple organ involvement. We report a case of a 64-year-old male patient who presented with symptoms of chronic rhinosinusitis, numbness, and pain in both lower
Phuong Nguyen Thi, Ngoc Nguyen Thi Anh, Hoa Dang Hong   +2 more
doaj   +1 more source

Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study [PDF]

, 2014
Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established.
Lo, Mindy S, Son, Mary Beth F, Sundel, Robert P, Zurakowski, David   +3 more
core   +1 more source

From Nerves to Vessels: Unmasking Churg‐Strauss Behind Polyneuropathy

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg‐Strauss vasculitis, is a rare systemic autoimmune disease. Neurological involvement is a significant complication. This report details a case of EGPA with severe, progressive polyneuropathy and atypical serological findings, highlighting diagnostic challenges and the ...
Hiba Antar, Sylvana Balhas, Zeinab El Mawla   +2 more
wiley   +1 more source

Rare Gain‐of‐Function Variants in IDH1 and IDH2 Confer Increased Risk of Immune‐Mediated Rheumatic Diseases

ACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Objective Gain‐of‐function variants in IDH1 and IDH2 are enriched among individuals with coexisting myeloid neoplasms and autoimmune diseases. However, the association between IDH1/IDH2 variants and rheumatic diseases independent of hematologic neoplasms remains unclear. We investigated the association between rare gain‐of‐function and loss‐of‐function
Mahmut S. Kaymakci, Mehmet Hocaoğlu, Kenneth J. Warrington, Amr H. Sawalha   +3 more
wiley   +1 more source

Intracerebral hemorrhage after IV tPA for stroke as early symptom of ANCA-associated vasculitis

eNeurologicalSci, 2017
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare diseases characterized by a necrotizing small-vessel vasculitis and circulating ANCA that comprise granulomatosis with polyangiitis, microscopic polyangiitis, and ...
Neda Zarghami Esfahani, Daniel M. Anderson, Connie Pieper, Harold P. Adams, Jr.   +3 more
doaj   +1 more source

Impaired function of endothelial progenitor cells in children with primary systemic vasculitis [PDF]

, 2015
INTRODUCTION: Previously, we demonstrated that children with active systemic vasculitis (SV) have higher circulating CD34 + CD133 + KDR+ endothelial progenitor cells (EPC); the function of these EPCs, and their relationship with disease activity in ...
Brogan, PA, Eleftheriou, D, Hong, Y, Klein, NJ   +3 more
core   +1 more source

The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Arthritis &Rheumatology, Volume 78, Issue 4, Page 970-975, April 2026.
Objective Ear, nose, and throat (ENT) manifestations are common in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). There is an unmet need for drugs to target these manifestations. Granuloma formation is characteristic of proteinase 3 (PR3)–AAV. In a zebrafish model, niclosamide inhibits PR3‐induced granuloma formation.
Benjamin Lim, Wendi Qian, Francis Dowling, Alan Salama, Rona M Smith   +4 more
wiley   +1 more source

Characteristics of articular syndrome in systemic vasculitis [PDF]

, 2017
The purpose of the study – investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as ...
Gashynova, K., Khaniukov, O., Syniachenko, O., Taktashov, H., Yehudina, Ye.   +4 more
core