Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders [PDF]
Frontiers in Psychiatry, 2018 Eotaxin-1/CCL11 is a chemokine originally implicated in the selective recruitment of eosinophils into inflammatory sites during allergic reactions, being thoroughly investigated in asthma, allergic rhinitis, and other eosinophil-related conditions ...
Antonio L. Teixeira +5 more
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Synephrine Inhibits Eotaxin-1 Expression via the STAT6 Signaling Pathway [PDF]
Molecules, 2014 Citrus contain various flavonoids and alkaloids that have multiple biological activities. It is known that the immature Citrus contains larger amounts of bioactive components, than do the mature plants. Although Citrus flavonoids are well known for their
Kyung-Baeg Roh +6 more
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Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration [PDF]
Cell Death and Disease, 2022 Infiltration of eosinophils is associated with and contributes to liver regeneration. Chemotaxis of eosinophils is orchestrated by the eotaxin family of chemoattractants. We report here that expression of eotaxin-1 (referred to as eotaxin hereafter), but
Zhiwen Fan +14 more
doaj +4 more sources
Frontiers in Immunology, 2015 The eosinophil was first named by the brilliant German scientist Paul Ehrlich in 1879, while he was experimenting with aniline dyes to stain blood cells and tissues. He also discovered neutrophils, basophils, and mast cells. The highly basic proteins in cytosolic granules of a small subpopulation of cells in human blood stained vivid pink with the acid
TIMOTHY JOHN WILLIAMS
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Distinct Roles Between Eotaxin 1 and Eotaxin 2 in Asthmatic Airways [PDF]
Clinical and Translational AllergyBackground Eotaxins (EOTs), primarily expressed in airway epithelial cells (AECs), act as chemoattractants for eosinophils in asthma pathogenesis. Recent studies have suggested that EOTs have additional functions beyond chemotaxis.
Soyoon Sim +5 more
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The “Aging Factor” Eotaxin-1 (CCL11) Is Detectable in Transfusion Blood Products and Increases with the Donor’s Age [PDF]
Frontiers in Aging Neuroscience, 2017 Background: High blood levels of the chemokine eotaxin-1 (CCL11) have recently been associated with aging and dementia, as well as impaired memory and learning in humans. Importantly, eotaxin-1 was shown to pass the blood-brain-barrier (BBB) and has been
Julia Hoefer +5 more
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Betel chewing and arecoline affects eotaxin-1, asthma and lung function. [PDF]
PLoS ONE, 2014 BackgroundBetel nut is commonly used in many countries. Despite evidence suggesting an association with asthma, few studies have investigated the connection between betel nut use and asthma; thus, the underlying mechanism for the association with asthma ...
Tsu-Nai Wang +13 more
doaj +6 more sources
Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. [PDF]
Sci Rep, 2021 AbstractEotaxin-1 (CCL11) induces the migration of different leukocyte types by interacting with CCR3. In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are pathogenic effectors and a major CCR3-expressing cell. The aim of this study was to investigate the expression and function of CCL11 in RA FLS.
Wakabayashi K +4 more
europepmc +5 more sources
Orally administered anti-eotaxin-1 monoclonal antibody is biologically active in the gut and alleviates immune-mediated hepatitis: A novel anti-inflammatory personalized therapeutic approach [PDF]
International Journal of Immunopathology and Pharmacology, 2021 Personalized therapies are designed to optimize the safety-to-efficacy ratio by selecting patients with higher response rates based on specific biomarkers.
Tawfik Khoury +3 more
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Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways [PDF]
Frontiers in Immunology, 2023 IntroductionEotaxin-1/CCL11 is a pivotal chemokine crucial for eosinophil homing to the lungs of asthmatic patients. Recent studies also suggest that CCL11 is involved in the aging process, as it is upregulated in elderly, and correlated with shorter ...
Patrícia Lavandoski +6 more
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