Results 91 to 100 of about 19,435 (196)

Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma

International Journal of Nanomedicine, 2020
Mingzhuo Cao,1 Mengling Zhan,1,2 Zheng Wang,1,2 Zeqian Wang,1,2 Xiu-Min Li,3 Mingsan Miao1 1Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450058, People’s Republic of China; 2College of Pharmacy, Henan ...
Cao M, Zhan M, Wang Z, Wang Z, Li XM, Miao M   +5 more
doaj  

Interleukin-19 Downregulates Interleukin-4-Induced Eotaxin Production in Human Nasal Fibroblasts

Allergology International, 2011
Background: Interleukin-19 (IL-19), a member of the IL-10 family, is characterized as the cytokine suppressing the release and function of several proinflammatory cytokines.
Masaaki Higashino, Tetsuji Takabayashi, Noboru Takahashi, Masayuki Okamoto, Norihiko Narita, Akihiro Kojima, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka, Shigeharu Fujieda   +9 more
doaj   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Resveratrol and its metabolites modulate cytokine‐mediated induction of eotaxin‐1 in human pulmonary artery endothelial cells

, 2013
Coronary heart disease (CHD) is a leading cause of death in many developed countries. Evidence has long implicated endothelial injury and inflammation as apical events in the pathogenesis of atherosclerosis, the primary cause of CHD.
Tze‐chen Hsieh, Susan C. Olson, Yang, Ching-Jen, Wu, Joseph M, Joseph M. Wu, Ching‐Jen Yang, Olson, Susan C, Hsieh, Tze-chen   +7 more
core   +1 more source

Tocilizumab for severe and refractory mucous membrane pemphigoid

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Elevated IL‐6 levels identified in mucous membrane pemphigoid support IL‐6 blockade, with tocilizumab demonstrating clinical benefit in nine patients with severe and refractory mucous membrane pemphigoid. Abstract Background Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease involving mucous membranes with a potentially ...
Billal Tedbirt, Maud Maho‐Vaillant, Julie Gueudry, Marie‐Laure Golinski, Marion Marcaillou, Blanche Bergeret, Guillaume Chambon, Pierre Bouchetemble, Soumeya Bekri, Abdellah Tebani, Hervé Maillard, Cécile Morice, Anais Vautier, Edgar‐Pierre Libert, Christelle Le Roux‐Villet, Marion Carrette, Olivier Boyer, Vivien Hébert, Sébastien Calbo, André Gillibert, Pascal Joly   +20 more
wiley   +1 more source

Migration of purified mouse eosinophils to IL-4 and IL-13 in the presence or absence of eotaxin-1.

, 2013
(A). Eosinophil chemotaxis to IL-4 (left panel) and IL-13 (right panel) in the presence (filled bars) or absence (open bars) of 30 nM eotaxin-1 was measured.
Nicola M. Heller (317848), William M. Gwinn (317849), Stephanie L. Constant (317851), Achsah D. Keegan (317852), Raymond P. Donnelly (317850)   +4 more
core   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

TSLP and CCL11/Eotaxin-1 secretion during rhinovirus-induced asthma exacerbation.

, 2016
Nasal airway protein levels of TSLP (A), CCL11/eotaxin-1 (B) in asthmatic children with PCR-confirmed rhinovirus and clinical wheezing (asthma; n = 20) vs. age-matched non-asthmatic children without clinical wheezing or rhinovirus (control; n = 20).
Geovanny F. Perez (2219266), Krishna Pancham (2219281), Humaira Mubeen (2219272), Shehlanoor Huseni (2219275), Justin Wang (422925), Mary C. Rose (410732), Gustavo Nino (183162), Anamaris M. Colberg-Poley (2219278), Stephen Eng (2219269), Dinesh K. Pillai (2219284), Aleeza Abbasi (2219287)   +10 more
core   +1 more source

Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils

Allergology International, 2000
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily responsible for degradation of the BM.
Izumi Kurosaki, Taku Satoh, Koji Murakami, Takeshi Tastumi, Noriyasu Mitani, Ikuo Saiki   +5 more
doaj   +1 more source

The Eotaxin-1/CCR3 Axis and Matrix Metalloproteinase-9 Are Critical in Anti-NC16A IgE-Induced Bullous Pemphigoid. [PDF]

J Immunol, 2023
Jordan TJM, Chen J, Li N, Burette S, Wan L, Chen L, Culton DA, Geng S, Googe P, Thomas NE, Diaz LA, Liu Z.   +11 more
europepmc   +1 more source