Results 81 to 90 of about 29,712,289 (205)

Eotaxin/CCL11 expression by infiltrating macrophages in rat heart transplants during ongoing acute rejection

, 2009
Eotaxin/CCL11 chemokine is expressed in different organs, including the heart, but its precise cellular origin in the heart is unknown. Eotaxin is associated with Th2-like responses and exerts its chemotactic effect through the chemokine receptor-3 (CCR3)
Martin Zweifel, Katja Matozan, Robert Driscoll, Matozan, Katja, Clemens Dahinden, Driscoll, Robert, Mohacsi, Paul, Mueller, Christoph, Christoph Mueller, Zweifel, Martin, Schaffner, Thomas, Paul Mohacsi, Thomas Schaffner, Dahinden, Clemens   +13 more
core   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma

International Journal of Nanomedicine, 2020
Mingzhuo Cao,1 Mengling Zhan,1,2 Zheng Wang,1,2 Zeqian Wang,1,2 Xiu-Min Li,3 Mingsan Miao1 1Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450058, People’s Republic of China; 2College of Pharmacy, Henan ...
Cao M, Zhan M, Wang Z, Wang Z, Li XM, Miao M   +5 more
doaj  

Interleukin-19 Downregulates Interleukin-4-Induced Eotaxin Production in Human Nasal Fibroblasts

Allergology International, 2011
Background: Interleukin-19 (IL-19), a member of the IL-10 family, is characterized as the cytokine suppressing the release and function of several proinflammatory cytokines.
Masaaki Higashino, Tetsuji Takabayashi, Noboru Takahashi, Masayuki Okamoto, Norihiko Narita, Akihiro Kojima, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka, Shigeharu Fujieda   +9 more
doaj   +1 more source

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis [PDF]

, 2018
Purpose: To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season.
Leimgruber, Annette, Lanz, René, Lurati, Floriana, Eperon, Simone, Guex-Crosier, Yan, Sauty, Alain   +5 more
core  

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils

Allergology International, 2000
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily responsible for degradation of the BM.
Izumi Kurosaki, Taku Satoh, Koji Murakami, Takeshi Tastumi, Noriyasu Mitani, Ikuo Saiki   +5 more
doaj   +1 more source

Caregiver sensitivity moderates effects of gestational inflammation on child ADHD symptoms

Journal of Child Psychology and Psychiatry, EarlyView.
Background Increased inflammation during pregnancy may increase the risk for child psychopathology, though prospective data remain preliminary. Child symptoms of attention‐deficit/hyperactivity disorder (ADHD) are particularly important due to ADHD's role as an early precursor of many later forms of externalizing and internalizing problems.
Elinor L. Sullivan, Jessica M. Tipsord, Elizabeth K. Nousen, Julia Williams, Sara Shao, Diana Vazquez Duque, Jennifer M. Loftis, Sarah L. Karalunas, Joel T. Nigg, Hanna C. Gustafsson   +9 more
wiley   +1 more source

The Eotaxin-1/CCR3 Axis and Matrix Metalloproteinase-9 Are Critical in Anti-NC16A IgE-Induced Bullous Pemphigoid. [PDF]

J Immunol, 2023
Jordan TJM, Chen J, Li N, Burette S, Wan L, Chen L, Culton DA, Geng S, Googe P, Thomas NE, Diaz LA, Liu Z.   +11 more
europepmc   +1 more source