Results 81 to 90 of about 19,435 (196)

Molecular Characterization of Non‐Specific Esophagitis Reveals a Distinct Non‐Eosinophilic Phenotype With Fibrotic Traits

Allergy, EarlyView.
This study comprehensively characterizes non‐specific esophagitis and elucidates eosinophil‐independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with GERD and other chronic inflammatory disorders such as EoE or lymphocytic esophagitis.
Marc Pfefferle, Darko Stojkov, Dagmar Simon, Emilie Gueguen, Marcin Wawrzyniak, Margaret H. Collins, Mirna Chehade, Evan S. Dellon, Glenn T. Furuta, Ikuo Hirano, Nirmala Gonsalves, Fouad J. Moawad, Luc Biedermann, Alain M. Schoepfer, Alex Straumann, Hans‐Uwe Simon, Thomas Greuter   +16 more
wiley   +1 more source

Unidirectional TSLP-induced secretion of CCL11/eotaxin-1 in HBEC.

, 2016
CCL11/eotaxin-1 is secreted apically (A) but not basally (B) by ALI-differentiated HBEC treated with TSLP (apical 10 ng/ml×48 h). Bars represent means ± SE of triplicate values from 3 experiments done with cells from 3 controls and 3 asthmatic donors ...
Geovanny F. Perez (2219266), Krishna Pancham (2219281), Humaira Mubeen (2219272), Shehlanoor Huseni (2219275), Justin Wang (422925), Mary C. Rose (410732), Gustavo Nino (183162), Anamaris M. Colberg-Poley (2219278), Stephen Eng (2219269), Dinesh K. Pillai (2219284), Aleeza Abbasi (2219287)   +10 more
core   +1 more source

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, EarlyView.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

Histamine H1 and H4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases

Allergology International, 2017
Background: This study investigated the histamine H1 and H4 receptors mRNA (H1R and H4R, respectively) expression on the ocular surface of patients with chronic forms of allergic conjunctival diseases to determine whether they can serve as biomarkers for
Noriko Inada, Jun Shoji, Yukiko Shiraki, Hiroshi Aso, Satoru Yamagami   +4 more
doaj   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, EarlyView.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Migration of bone marrow-derived eosinophils (bmEos) from γC^+/+ and γC^−/− mice to eotaxin-1.

, 2013
Eosinophils were differentiated from the bone marrow of γC+/+ (black bars) or γC−/− (open bars) mice in vitro as described in the Methods. The cells were either untreated or primed with 10 ng/mL IL-4 for 30 min prior to placement into the upper chamber ...
Nicola M. Heller (317848), William M. Gwinn (317849), Stephanie L. Constant (317851), Achsah D. Keegan (317852), Raymond P. Donnelly (317850)   +4 more
core   +1 more source

Difference of Serum Cytokine Profile in Allergic Asthma Patients According to Disease Severity

Journal of Asthma and Allergy, 2022
Lin Sun,1– 3,* Bo Peng,1– 3,* Jun Zhou,1– 3 Ping Wang,1 Yuqing Mo,4 Guofang Xu,1 Yi Tao,1 Hejie Song,1– 3 Wei Tang,1– 3 Meiling Jin4 1Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of ...
Sun L, Peng B, Zhou J, Wang P, Mo Y, Xu G, Tao Y, Song H, Tang W, Jin M   +9 more
doaj  

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Human eosinophil adhesion and degranulation stimulated with eotaxin and RANTES in vitro: Lack of interaction with nitric oxide

BMC Pulmonary Medicine, 2008
Background Airway eosinophilia is considered a central event in the pathogenesis of asthma. The toxic components of eosinophils are thought to be important in inducing bronchial mucosal injury and dysfunction.
Zanesco Angelina, de Nucci Gilberto, Condino-Neto Antonio, Nowill Alexandre, Franchi Gilberto, Lintomen Letícia, Antunes Edson   +6 more
doaj   +1 more source

Correlation of arecoline and arecaidine levels with eotaxin-1 levels and lung function in male asthmatics.

, 2014
*Spearman correlation coefficient.Arecoline, arecaidine, IgE, hs-CRP, leptin, TGF-β1 and eotaxin-1 levels were logarithmically transformed before statistical testing to meet the assumption of normal distribution.
Chin-Chou Wang (381926), Meng-Chih Lin (162902), Ming-Shyan Huang (244444), Chao-Chien Wu (540961), Cleusa P. Ferri (180466), Ying-Chin Ko (540962), Tsai-Hui Duh (540957), Robert Stewart (34430), Tsu-Nai Wang (514867), Chih-Hung Lee (188177), Shang-Lun Chiang (540959), Chau-Chyun Sheu (524362), Vincent Chin-Hung Chen (540960), Ping-Ho Chen (540958)   +13 more
core   +1 more source