Results 71 to 80 of about 19,435 (196)

CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age

Cells, 2019
CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice.
Simone Lieschke, Bozena Zechmeister, Matteo Haupt, Xuan Zheng, Fengyan Jin, Katharina Hein, Martin S. Weber, Dirk M. Hermann, Mathias Bähr, Ertugrul Kilic, Thorsten R. Doeppner   +10 more
doaj   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle

, 2008
Background and purpose: The glycosaminoglycan heparin has anti-inflammatory activity and is exclusively found in mast cells, which are localized within airway smooth muscle (ASM) bundles of asthmatic airways. Interleukin (IL)-13 induces the production of
C Karner, O'Connor, B J, B J O'Connor, S J Hirst, K Mahn, Karner, C, Kanabar, V, Hirst, S J, Mahn, K, D E Simcock, Page, C, Simcock, D E, V Kanabar, C P Page   +13 more
core   +1 more source

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

Images of immunohistochemical staining of eotaxin-1 in colorectal tissue from patients with CRC

, 2011
Copyright information:Taken from "Analysis of single nucleotide polymorphism in the promoter and protein expression of the chemokine Eotaxin-1 in colorectal cancer patients"http://www.wjso.com/content/5/1/84World Journal of Surgical Oncology 2007;5():84 ...
Anders Hugander (34380), Jan Dimberg (34382), Sture Löfgren (34379), Olaf Dienus (34381), Dick Wågsäter (34378)   +4 more
core   +1 more source

Linear correlation of TSLP and CCL11/Eotaxin-1 secretion during rhinovirus-induced asthma exacerbation.

, 2016
(A) Positive linear relationship of nasal airway protein levels of TSLP and CCL11/eotaxin-1 in subjects with rhinovirus-induced asthma exacerbation ...
Geovanny F. Perez (2219266), Krishna Pancham (2219281), Humaira Mubeen (2219272), Shehlanoor Huseni (2219275), Justin Wang (422925), Mary C. Rose (410732), Gustavo Nino (183162), Anamaris M. Colberg-Poley (2219278), Stephen Eng (2219269), Dinesh K. Pillai (2219284), Aleeza Abbasi (2219287)   +10 more
core   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis Expressão de RANTES, eotaxina-2, ICAM-1, LFA-1 e CCR-3 em pacientes com rinossinusite crônica associada à polipose nasossinusal

Acta Cirúrgica Brasileira, 2012
PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa.
Fransérgio Emílio Cavallari, Fabiana Cardoso Pereira Valera, Aline Jorge Gallego, Rafael Rossell Malinsky, Daniel Salgado Küpper, Cristiane Milanezi, João Santana da Silva, Edwin Tamashiro, Wilma Terezinha Anselmo-Lima   +8 more
doaj   +1 more source

Renal expression of cytokines and chemokines in diabetic nephropathy

BMC Nephrology, 2020
Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Inflammatory mediators have been implicated in the pathogenesis of DN, thus considered an inflammatory disease.
Liliane Silvano Araújo, Bianca Gonçalves Silva Torquato, Crislaine Aparecida da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Ana Luisa Monteiro dos Santos Martins, Marcos Vinícius da Silva, Marlene Antônia dos Reis, Juliana Reis Machado   +7 more
doaj   +1 more source