Results 1 to 10 of about 223 (65)

Expression and Immunological Characterization of African Swine Fever Virus EP153R Protein for Serodiagnosis and Its Delivery via a Recombinant PRRSV Live Vector [PDF]

Vaccines
Background/Objectives: African Swine Fever (ASF), caused by the African Swine Fever Virus (ASFV), is a highly contagious and lethal disease in pigs, for which no recognized safe and effective vaccine is currently available.
Meng Luo, Wenna Shuai, Ziqiang Guo, Jiale Li, Liwei Li, Yanjun Zhou, Yifeng Jiang, Wu Tong, Yifan Zeng, Jinbin Wang, Li Zhao, Fei Gao   +11 more
doaj   +3 more sources

Double Deletion of EP402R and EP153R in the Attenuated Lv17/WB/Rie1 African Swine Fever Virus (ASFV) Enhances Safety, Provides DIVA Compatibility, and Confers Complete Protection Against a Genotype II Virulent Strain [PDF]

Vaccines
Background/Objectives: African swine fever virus (ASFV) is a devastating disease affecting domestic and wild suids and causing significant economic losses in the global pig industry.
Carmina Gallardo, István Mészáros, Alejandro Soler, Jovita Fernandez-Pinero, Erwin van den Born, Alicia Simón, Nadia Casado, Raquel Nieto, Covadonga Perez, Irene Aldea, Vicente Lopez-Chavarrias, Eszter Göltl, Ferenc Olasz, Tibor Magyar, Zoltán Zádori, José Manuel Sánchez-Vizcaíno, Marisa Arias   +16 more
doaj   +5 more sources

Protection Evaluation of a Five-Gene-Deleted African Swine Fever Virus Vaccine Candidate Against Homologous Challenge [PDF]

Frontiers in Microbiology, 2022
African swine fever virus (ASFV) represents a serious threat to the global swine industry, and there are no safe or commercially available vaccines. Previous studies have demonstrated that inactivated vaccines do not provide sufficient protection against
Zhenhua Xie, Zhenhua Xie, Yingnan Liu, Yingnan Liu, Dongdong Di, Jingyi Liu, Jingyi Liu, Lang Gong, Zongyan Chen, Zongyan Chen, Yao Li, Yao Li, Wanqi Yu, Wanqi Yu, Lu Lv, Lu Lv, Qiuping Zhong, Qiuping Zhong, Yingying Song, Yingying Song, Xinxin Liao, Xinxin Liao, Qingqing Song, Heng Wang, Hongjun Chen, Hongjun Chen   +25 more
doaj   +2 more sources

Deletion of CD2-Like (CD2v) and C-Type Lectin-Like (EP153R) Genes from African Swine Fever Virus Georgia-∆9GL Abrogates Its Effectiveness as an Experimental Vaccine [PDF]

Viruses, 2020
African swine fever virus (ASFV) is currently the most dreaded infectious disease affecting the global swine production industry. There is no commercial vaccine available, making the culling of infected animals the current solution to control outbreaks ...
Douglas P. Gladue, Vivian O’Donnell, Elizabeth Ramirez-Medina, Ayushi Rai, Sarah Pruitt, Elizabeth A. Vuono, Ediane Silva, Lauro Velazquez-Salinas, Manuel V. Borca   +8 more
doaj   +3 more sources

A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein [PDF]

Emerging Microbes and Infections, 2023
African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in ...
Anusyah Rathakrishnan, Ana L. Reis, Vlad Petrovan, Lynnette C. Goatley, Katy Moffat, Yuan Lui, Mai T. Vuong, Shinji Ikemizu, Simon J. Davis, Linda K. Dixon   +9 more
doaj   +2 more sources

Role of African Swine Fever Virus Proteins EP153R and EP402R in Reducing Viral Persistence in Blood and Virulence in Pigs Infected with BeninΔDP148R. [PDF]

J Virol, 2022
African swine fever virus (ASFV) causes a disease of domestic pigs and wild boar which results in death of almost all infected animals. The disease has a high economic impact, and no vaccine is available.
Petrovan V, Rathakrishnan A, Islam M, Goatley LC, Moffat K, Sanchez-Cordon PJ, Reis AL, Dixon LK.   +7 more
europepmc   +4 more sources

A Novel Prototype African Swine Fever Virus DIVA (Differentiation Between Infected and Vaccinated Animals) Serological Assay Based on the Detection of Antibodies Against the pEP153R, eGFP, and p72 Proteins [PDF]

Vaccines
Background/Objectives: African Swine Fever (ASF) is one of the most significant infectious diseases affecting both domestic pig and wild boar populations, leading to substantial economic and biosanitary consequences.
Gabriela González-García, Carmina Gallardo, Mercedes Montón, Sandra Barroso-Arévalo, Nadia Casado, José Ángel Barasona, José Manuel Sánchez-Vizcaíno, Ángel Venteo, Patricia Sastre, Paloma Rueda   +9 more
doaj   +2 more sources

Development and efficacy of a novel mRNA cocktail for the delivery of African swine fever virus antigens and induction of immune responses [PDF]

Microbiology Spectrum
African swine fever (ASF) is a highly lethal infectious disease affecting pigs. Although several vaccine formulations have been developed to protect from ASF virus (ASFV) infection, none have yet provided complete protection without side effects or the ...
Xing Hu, Cong Liu, Nino Rcheulishvili, Yunzhi Wang, Ting Xiong, Fengfei Xie, Xingyun Wang, Ruiai Chen, Peng George Wang, Yunjiao He   +9 more
doaj   +2 more sources

Modulation of Autophagy–Lysosome Axis by African Swine Fever Virus and Its Encoded Protein pEP153R [PDF]

Current Issues in Molecular Biology
The autophagy–lysosome axis is an evolutionarily conserved intracellular degradation pathway which constitutes an important component of host innate immunity against microbial infections.
Si-Yu Bai, Wenlian Weng, Hua Wang, Zhiying Cui, Jiajun Wu, Yajin Qu, Yuxin Hao, Peng Gao, Yongning Zhang, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang   +13 more
doaj   +2 more sources

Deletion of B125R increases protection induced by a genotype II African swine fever vaccine candidate [PDF]

npj Vaccines
A modified live attenuated African swine fever genotype II virus, GΔDKE-CmutQ96R/K108D, with deletions of three genes, DP148R, EP153R, and K145R and expressing a mutated CD2v protein with a non-haemadsorbing phenotype, was further modified by first ...
Anusyah Rathakrishnan, Ana Luisa Reis, Katy Moffat, Lynnette Goatley, Elisenda Viaplana, Jose Carlos Mancera, Alicia Urniza, Linda K. Dixon   +7 more
doaj   +2 more sources