Results 91 to 100 of about 11,193 (295)

Prostaglandin E2 and Its Receptor EP2 Modulate Macrophage Activation and Fusion in Vitro

, 2020
The foreign body response (FBR) has impaired progress of new implantable medical devices through its hallmark of chronic inflammation and foreign body giant cell (FBGC) formation leading to fibrous encapsulation.
Casey Vanderheyden, Leila S. Saleh (8458320), Andrew Frederickson, Casey Vanderheyden (8458323), Leila S. Saleh, Stephanie J. Bryant (1315149), Andrew Frederickson (8458326), Stephanie J. Bryant   +7 more
core   +1 more source

Development of Advanced Theory of Mind Abilities During Adolescence: Prosocial Behavior and Presence of a Real Interlocutor Matter

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Advanced Theory of Mind (ToM) refers to the ability to quickly appreciate the mental states of an interlocutor, depending on the conversational context, and to rapidly adjust one's own mental representations in response to verbal feedback from that interlocutor. Although these abilities continue to develop during adolescence, they
Clara Grégoire, Stéphane Rauzy, Maud Champagne‐Lavau   +2 more
wiley   +1 more source

PGE2 Promotes the Migration of Mesenchymal Stem Cells through the Activation of FAK and ERK1/2 Pathway

Stem Cells International, 2017
A critical step of MSCs therapy is dependent on its ability to migrate into the sites of injury, so various approaches have been introduced to boost the migratory ability of MSCs.
Xiaomin Lu, Jibin Han, Xiuping Xu, Jingyuan Xu, Ling Liu, Yingzi Huang, Yi Yang, Haibo Qiu   +7 more
doaj   +1 more source

EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation

, 2019
High levels of PGE2 have been implicated in the pathogenesis of intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) and peritonitis. However, PGE2 has a paradoxical effect: its low levels promote intestinal homeostasis, whereas high
Delaplain, Patrick, Mubina Isani, Wang, Jin, Isani, Mubina, Jordan Bowling, Bell, Brandon, Jin Wang, Illingworth, Laura, Joanna Lim, Ford, Henri R, Kavarian, Patil, Patil Kavarian, Jamie Golden, Oswaldo Escobar, Henri R. Ford, Gayer, Christopher P, Christopher P. Gayer, Escobar, Oswaldo, Grishin, Anatoly, Patrick Delaplain, Golden, Jamie, Laura Illingworth, Bowling, Jordan, Lim, Joanna, Brandon Bell, Anatoly Grishin   +25 more
core   +1 more source

Navigating AI Convergence in Human–Artificial Intelligence Teams: A Signaling Theory Approach

Journal of Organizational Behavior, EarlyView.
ABSTRACT Teams that combine human intelligence with artificial intelligence (AI) have become indispensable for solving complex tasks in various decision‐making contexts in modern organizations. However, the factors that contribute to AI convergence, where human team members align their decisions with those of their AI counterparts, still remain unclear.
Andria Smith, Hunter Phoenix van Wagoner, Ksenia Keplinger, Can Celebi   +3 more
wiley   +1 more source

Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

, 2016
: Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases.
Ray Dingledine, Jianxiong Jiang, Myung-soon Yang, Thota Ganesh   +3 more
core  

Sharing Good News at Work to Collaborate and to Self‐Enhance: A Motivational and Reputational Perspective on Workplace Interpersonal Capitalization

Journal of Organizational Behavior, EarlyView.
ABSTRACT Employees routinely experience work‐related positive events. In the wake of these events, employees sometimes share the good news with coworkers—a phenomenon known as workplace interpersonal capitalization. Research shows that such capitalization matters for how employees feel and act.
Trevor Watkins, Ji Koung Kim, Anthony C. Klotz, Satish Krishnan   +3 more
wiley   +1 more source

Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor [PDF]

, 1999
Prostaglandins (PGs) are bioactive lipids that modulate a broad spectrum of biologic processes including reproduction and circulatory homeostasis. Although reproductive functions of mammals are influenced by PGs at numerous levels, including ovulation ...
Kim, Hyung-Suk, Stephen L. Tilley, Koller, Beverly H., Hyung-Suk Kim, Patrick J. Flannery, Beverly H. Koller, Coffman, Thomas M., Thomas M. Coffman, Flannery, Patrick J., Elizabeth H. Hicks, Tilley, Stephen L., Audoly, Laurent P., Hicks, Elizabeth H., Laurent P. Audoly   +13 more
core   +1 more source

The Family Job Hunt: The Influence of Family Member Active Job Search Behavior on Family–Work Conflict

Journal of Organizational Behavior, EarlyView.
ABSTRACT Existing research shows that family members may draw on work and personal resources to support job seekers. This research, however, explores the reverse: how the behaviors of job‐seeking family members may impact non‐job‐seekers' ability to manage work and life demands.
Michael Halinski, Jennifer A. Harrison
wiley   +1 more source

Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells

Nature Communications
While prostaglandin E2 (PGE2) is produced in human tumor microenvironment (TME), its role therein remains poorly understood. Here, we examine this issue by comparative single-cell RNA sequencing of immune cells infiltrating human cancers and syngeneic ...
Siwakorn Punyawatthananukool, Ryuma Matsuura, Thamrong Wongchang, Nao Katsurada, Tatsuaki Tsuruyama, Masaki Tajima, Yutaka Enomoto, Toshio Kitamura, Masahiro Kawashima, Masakazu Toi, Koji Yamanoi, Junzo Hamanishi, Shigeo Hisamori, Kazutaka Obama, Varodom Charoensawan, Dean Thumkeo, Shuh Narumiya   +16 more
doaj   +1 more source