Results 241 to 250 of about 712,631 (292)

Synthesis, Modeling, and Biological Properties of Fluoroprostacyclin Analogues: Potent Agonists for Prostanoid Receptors. [PDF]

J Med Chem
Jing C, Perez-Powell I, Baars H, Mallah S, Trory JS, Corey RA, Mundell SJ, Xu X, Tromans J, Moore SF, Arthur CJ, Hers I, Aggarwal VK.   +12 more
europepmc   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome. [PDF]

Epilepsia Open
Pain E, Kapatel Y, Singh PK, Jones KL, Selvakumaran J, Malerba A, Lucchesi W, Rutherford T, Gurnett CA, Walker MC, Williams RSB.   +10 more
europepmc   +1 more source

Structural basis and physiological significance of non-canonical G_s coupling to the melatonin MT₁ receptor. [PDF]

Nat Commun
Oishi A, Okamoto HH, Ikegami K, McHugh R, Masri B, Kusakizako T, Kobayashi K, Takaki A, Karamitri A, Cecon E, Dam J, Nagase M, Tikhonova IG, Nureki O, Jockers R.   +14 more
europepmc   +1 more source

Sex-dependent effects of psychedelics: review of evidence from rodent models. [PDF]

Front Psychiatry
Marecki R, Zaniewska W, Hamed A, Waszkiewicz N, Baker JJ, Łukasiewicz K.   +5 more
europepmc   +1 more source

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Prostaglandin E2 EP receptors in cardiovascular disease: An update

Biochemical Pharmacology, 2022
This review article provides an update for the role of prostaglandin E2 receptors (EP1, EP2, EP3 and EP4) in cardiovascular disease. Where possible we have reported citations from the last decade although this was not possible for all of the topics covered due to the paucity of publications.
Timothy D. Bryson, Pamela Harding
openaire   +2 more sources

Structure of the thromboxane receptor antagonist EP 092

Acta Crystallographica Section C Crystal Structure Communications, 1990
7-(3-[1-(4-Phenylthiosemicarbazono)ethyl]-bicyclo[2.2.1]hept-2- yl)-5-heptenoic acid, C23H31N3-O2S, Mr = 413.7, monoclinic, P2(1)/a, a = 12.9650 (7), b = 11.2081 (6), c = 16.8941 (12) A, beta = 110.452 (5) degrees, V = 2300.2 A3, Z = 4, Dx = 1.194 g cm-3, Mo K alpha, lambda = 0.71073 A, mu = 1.55 cm-1, F(000) = 888, T = 298 K.
A, McAlpine, L, Sawyer, P, Taylor, A J, Blake   +3 more
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Prostaglandin EP receptor subtypes and gastric cytoprotection

InflammoPharmacology, 2002
This article reviews recent studies dealing with the relationship between the cytoprotective action of PGE2 and the EP receptor subtypes in the gastric mucosa. Gastric cytoprotection afforded by PGE2 was mimicked by EP1 agonists and attenuated by the EP1 antagonist.
Koji Takeuchi, Shoko Hase, Masanori Takeeda, Masato Nakashima, Aya Yokota   +4 more
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Immunolocalization of prostanoid EP receptor isotypes in human trabecular meshwork

Current Eye Research, 2004
To assess the localization of the EP-type prostanoid receptors in the human trabecular meshwork (TM) and to determine their spatial distribution in relation to the contractile a-smooth muscle actin fibres.Cryosections of human anterior segments were obtained from 17 different donors and immunostained with different EP receptor subtype specific ...
Willem, Kamphuis, Andrea, Schneemann, Hitoshi, Shichi, Lidy, Broersma, Philip F J, Hoyng   +4 more
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Prostaglandin EP receptors: Targets for treatment and prevention of colorectal cancer?

Molecular Cancer Therapeutics, 2004
Abstract The importance of the prostaglandin (PG) synthesis pathway, particularly the rate-limiting enzymatic step catalyzed by cyclooxygenase, to colorectal carcinogenesis and development of novel anticolorectal cancer therapy is well established. The predominant PG species in benign and malignant colorectal tumors is PGE2.
Mark A, Hull, Stanley C W, Ko, Gillian, Hawcroft   +2 more
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Inhibitory prostanoid EP receptors in human non-pregnant myometrium

European Journal of Pharmacology, 1999
Prostanoid EP receptor agonists relaxed cloprostenol-stimulated contraction of human non-pregnant myometrium in vitro with pEC50 values of (n = 4): prostaglandin E2, 7.8+/-0.2 > 1-OH prostaglandin E1, 7.2+/-0.3 > misoprostol, 6.6+/-0.1 > 16,16-dimethyl prostaglandin E2, 6.3+/-0.7 > butaprost, 5.7+/-0.3 > 11-deoxy prostaglandin E1, 5.5+/-0.2 = AH13205 ((
C J, Hillock, D J, Crankshaw
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