Results 251 to 260 of about 712,631 (292)

EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection

Neuropharmacology, 2001
The effect of EP 91073, EP 51389, EP 70555 and EP 51216, peptide analogues of the growth hormone releasing peptide hexarelin, on penile erection induced by EP 80661 or EP 60761 injected into the paraventricular nucleus of the hypothalamus, was studied in male rats.
M R, Melis, S, Succu, M S, Spano, R, Deghenghi, A, Argiolas   +4 more
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Prostaglandin E (EP) receptor subtypes and sleep

NeuroReport, 2000
Prostaglandin (PG) E2 reportedly augmented wakefulness when continuously infused into the third ventricle of the rat brain, whereas it promoted sleep when continuously infused into the subarachnoid space of the ventral surface zone of the rostral basal forebrain, which was designated previously as a PGD2-sensitive sleep-promoting zone (PGD2-SZ). In the
Y, Yoshida, H, Matsumura, T, Nakajima, M, Mandai, T, Urakami, K, Kuroda, H, Yoneda   +6 more
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EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat

Journal of Neurophysiology, 1996
1. Our previous studies, in which we used in vitro canine testispermatic nerve preparations, showed that prostaglandin E2 (PGE2) augments both bradykinin (BK)- and heat-induced discharges of polymodal receptors. However, the PGE2 concentration required to augment the BK responses were 100 times lower than those necessary for the heat responses ...
T, Kumazawa, K, Mizumura, H, Koda, H, Fukusako   +3 more
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The role of prostaglandin EP receptors in a model of glomerulonephritis

2013
Prostaglandin E2 (PGE2) interacts with four E-Prostanoid (EP) receptor subtypes---designated EP1--4 . In glomerulonephritis (GN), a renal inflammatory disease, inhibition of enhanced renal PGE2 synthesis by nonsteroidal-anti-inflammatory drugs (NSAIDs), results in both beneficial anti-proteinuric effects and deleterious side effects on renal blood flow
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Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation

Biochemical and Biophysical Research Communications, 2005
Regulation of chondrogenesis and chondrocyte maturation by prostaglandins has been a topic of interest during recent years. Particular focus on this area derives from the realization that inhibition of prostaglandin synthesis with non-steroidal anti-inflammatory drugs could impact these cartilage-related processes which are important in skeletal ...
Christine A, Clark, Edward M, Schwarz, Xinping, Zhang, Navid M, Ziran, Hicham, Drissi, Regis J, O'Keefe, Michael J, Zuscik   +6 more
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Cellular distribution of prostanoid EP receptors mRNA in the rat gastrointestinal tract

Prostaglandins & Other Lipid Mediators, 2000
The inhibition of PGE(2) synthesis resulting from sustained NSAIDs therapy has been linked to gastrointestinal irritations and ulceration. The multiple physiological effects of PGE(2) in the gut are mediated through the activation of four receptors termed EP(1-4).
A, Northey, D, Denis, M, Cirino, K M, Metters, F, Nantel   +4 more
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Characterisation of the EP-receptor mediating dilatation and potentiation of inflammation in rabbit skin

Prostaglandins, 1995
The interactions of bradykinin (BK) and FMLP (a leukocyte-dependent mediator of inflammation) with thirteen prostaglandin E analogs have been investigated in a rabbit skin model of inflammation. The PGE analogs were chosen with a view to defining the EP-receptor subtypes involved.
R A, Armstrong, C, Marr, R L, Jones
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Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermis.

The Journal of investigative dermatology, 2005
Four prostaglandin (PG)E(2) receptors have been described, termed E-series prostaglandin receptors (EP(1)-EP(4)), that can be further subclassified as low-affinity (EP(1) and EP(2)) or high-affinity (EP(3) and EP(4)) receptors. Activation of the low-affinity PGE(2) receptors is likely to be important in mediating the actions of the high levels of PGE(2)
Raymond L, Konger, Steven D, Billings, Angela B, Thompson, Akira, Morimiya, Jack H, Ladenson, Yvonne, Landt, Alice P, Pentland, Sunil, Badve   +7 more
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Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep

Prostaglandins, 1985
The thromboxane receptor antagonist EP 092 inhibits the acute pulmonary vascular response to E. coli endotoxin in the anaesthetized, closed-chest sheep. The increase in the TXB2 level in arterial blood was not suppressed by EP 092. Intravenous infusion of the thromboxane mimetic 11,9-epoxymethano PGH2, but not PGF2 alpha, raises pulmonary artery ...
R A, Armstrong, R L, Jones, N H, Wilson
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The prostaglandin E₂ EP₄ receptor : the elucidation of agonist mediated receptor regulation and a novel therapeutic role for an EP₄ agonist in allergic lung inflammation

2006
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