Results 61 to 70 of about 25,194 (189)

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish.

PLoS Biology, 2023
Idiopathic scoliosis (IS) is the most common spinal deformity diagnosed in childhood or early adolescence, while the underlying pathogenesis of this serious condition remains largely unknown.
Haibo Xie, Yunsi Kang, Junjun Liu, Min Huang, Zhicheng Dai, Jiale Shi, Shuo Wang, Lanqin Li, Yuan Li, Pengfei Zheng, Yi Sun, Qize Han, Jingjing Zhang, Zezhang Zhu, Leilei Xu, Pamela C Yelick, Muqing Cao, Chengtian Zhao   +17 more
doaj   +1 more source

Cilia organize ependymal planar polarity

, 2010
Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain. Most ependymal cells are born prenatally and are derived from radial glia.
García-Verdugo, Jose Manuel, Alvarez-Buylla, Arturo, Mirzadeh, Zaman, Soriano-Navarro, Mario, Han, Young-Goo   +4 more
core   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas

Brain Pathology, EarlyView.
Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (ADAPTR) recommendations for ependymomas in resource‐restrained settings (RL = resource level; created in BioRender). Abstract Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults.
Laveniya Satgunaseelan, Michael E. Buckland, Geeta Chacko, Kenta Masui, Junji Shibahara, Vani Santosh, Maysa Al‐Hussaini, Sung‐Hye Park, Tarik Tihan, Ho‐Keung Ng, Pieter Wesseling, David N. Louis, Chitra Sarkar, Takashi Komori   +13 more
wiley   +1 more source

Single-cell RNA-sequencing of spinal cord ependymal cells from FOXJ1-EGFP mice

, 2022
The spinal cord neural stem cell potential is contained within the ependymal cells lining the central canal. Ependymal cells are, however, heterogeneous and we know little about what this reflects.
Rodrigo Albors, Aida, Molecular Cell and Developmental Biology, Storey, Kate   +2 more
core   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Acute viral encephalitis impacts dense‐core amyloid plaque pathology and dysregulates myeloid responses to amyloid plaques

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Recent epidemiological datasets have associated viral encephalitis exposure (i.e., viral‐induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.
Dominic Ibarra Javonillo, Susana Furman, Lucas Le, Kellie Fernandez, Jazmyn Mulford, Vidushi Singla, Roshni Jha, Kate Inman Tsourmas, Nellie E. Kwang, Kim N. Green, Thomas E. Lane   +10 more
wiley   +1 more source

Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets

IBRO Neuroscience Reports
In all epithelial cells, the adherent junctions (AJs) with cadherin as the core play an important role in the maintenance of the connection and the formation of apical-basal polarity. The ependymal cells close to the ventricular system rely on AJs with N-
Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao   +13 more
doaj   +1 more source

In utero ventriculosubgaleal shunt placement in a fetal lamb model: Phase 1 technical insights

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Background Progressive ventriculomegaly and the resulting irreversible brain damage may be mitigated through timely diversion prenatal intervention. While ventriculosubgaleal shunt (VSGS) is commonly performed postnatally in premature infants, in utero placement is unexplored.
Shohra Qaderi, Weston T. Northam, Soner Duru, Eyal Krispin, Nikan Zargarzadeh, Ali Javinani, Jose L. Peiro, Hamidreza Forourtan, Braxton Forde, Syril James, Scott A. Shainker, Arthur Nedder, Brittany Pattison, Lana Vasung, Lucas Peiro, Ryne A. Didier, Michaela K. Farber, Sebastian Seifert, Darren B. Orbach, P. Ellen Grant, Ramen H. Chmait, Benjamin C. Warf, Kjersti Aagaard, Yves Ville, Alireza A. Shamshirsaz   +24 more
wiley   +1 more source