Results 91 to 100 of about 2,351 (180)

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy

Allergy, Volume 80, Issue 10, Page 2824-2836, October 2025.
We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg‐derived IL‐10 is important for controlling EoE, but that Breg expansion and function are impaired in this condition. We identify IFNγ as a key negative regulator of Breg function in mice and patients with EoE. Bregs, regulatory B
Rachel L. Clement, Julie Dilollo, Eric M. Rodríguez‐López, Cleandre M. Guerrier, David A. Hill   +4 more
wiley   +1 more source

Current trends in peanut allergy immunotherapy: a review

Alergologia Polska
Peanut allergy (PA) poses significant clinical challenges due to its potentially life-threatening nature and increasing prevalence, particularly in children.
Klementyna Łyżwa, Anna Krupa-Łaska, Joanna Zielińska, Marek Kulus, Katarzyna Grzela   +4 more
doaj   +1 more source

Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy

Frontiers in Immunology, 2020
IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening ...
Ann-Marie Malby Schoos, Ann-Marie Malby Schoos, Dominique Bullens, Dominique Bullens, Bo Lund Chawes, Joana Costa, Liselot De Vlieger, Audrey DunnGalvin, Audrey DunnGalvin, Michelle M. Epstein, Johan Garssen, Johan Garssen, Christiane Hilger, Karen Knipping, Karen Knipping, Annette Kuehn, Dragan Mijakoski, Dragan Mijakoski, Daniel Munblit, Daniel Munblit, Nikita A. Nekliudov, Cevdet Ozdemir, Cevdet Ozdemir, Karine Patient, Diego Peroni, Sasho Stoleski, Sasho Stoleski, Eva Stylianou, Mirjana Tukalj, Mirjana Tukalj, Mirjana Tukalj, Kitty Verhoeckx, Mihaela Zidarn, Willem van de Veen, Willem van de Veen   +34 more
doaj   +1 more source

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]

, 2017
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
core   +3 more sources

A Practice Research Study of How Youth Understand and Manage Risks Associated With Their Food Allergy

Journal of Advanced Nursing, Volume 81, Issue 10, Page 6855-6866, October 2025.
ABSTRACT Aim To explore how youth understand and manage risk associated with food allergy in everyday life, aiming to inform future advanced nursing and care initiatives. Design Qualitative study based on critical psychological practice research. Methods Data was generated through participant observation and informal interviews during a 2‐day camp with
Britt Egmose, Dorthe S. Nielsen, Carsten Bindslev‐Jensen, Charlotte G. Mørtz, Lotte Huniche   +4 more
wiley   +1 more source

IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy. [PDF]

, 2013
IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting the protective T regulatory cells in allergic asthma. TH17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced ...
Finotto, S., Graser, A., Koch, S., Lehr, H.A., Mousset, S., Reinhardt, C., Reppert, S., Rieker, R., Ubel, C., Zimmermann, T.   +9 more
core   +2 more sources

Topographical variations in the skin barrier and their role in disease pathogenesis

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 7, Page 1228-1238, July 2025.
Unlike the gut, the skin appears uniform at first glance. However, histological and molecular biological research has revealed significant regional variations in the composition and function of its main barrier elements. In this review, we describe the topographical differences of four barrier elements in healthy skin: microbiome, chemical, physical ...
Z. Dajnoki, A. Kapitány, K. Eyerich, S. Eyerich, D. Törőcsik, A. Szegedi   +5 more
wiley   +1 more source

Food Allergen Immunotherapy in the Treatment of Patients with IgE-Mediated Food Allergy

Medicina
The prevalence of allergic diseases, including food allergy, is increasing, especially in developed countries. Implementation of an elimination diet is not a sufficient therapeutic strategy in patients with food allergy, whose quality of life is ...
Mirjana Turkalj, Adrijana Miletić Gospić, Ivona Višekruna Džidić, Ivana Banić   +3 more
doaj   +1 more source

Trajectories of allergic diseases in children: Destination unknown?

Pediatric Allergy and Immunology, Volume 36, Issue 7, July 2025.
Abstract The trajectories of allergic diseases represent one of the most currently debated topics both when referred to childhood and likewise adulthood. Data from cohorts show their heterogeneity as well as the key role of genetic and environmental factors.
Birgit Kalb, Ekaterina Khaleva, Mattia Giovannini, Karine Adel‐Patient, Flore Amat, Stefania Arasi, Susanne Lau, Antonio Nieto, Bianca Schaub, Marie Standl, Jonathan O'B Hourihane, Philippe Eigenmann, Antoine Deschildre, on behalf of the EAACI‐Clemens von Pirquet Foundation   +13 more
wiley   +1 more source

New modalities of allergen immunotherapy

Human Vaccines & Immunotherapeutics, 2018
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and ...
Manish Ramesh, Merhunisa Karagic
doaj   +1 more source