Results 101 to 110 of about 274,722 (228)

Adjuvanted Immunotherapy Approaches for Peanut Allergy

Frontiers in Immunology, 2018
Food allergies are a growing public health concern with an estimated 8% of US children affected. Peanut allergies are also on the rise and often do not spontaneously resolve, leaving individuals at-risk for potentially life-threatening anaphylaxis ...
Brandi T. Johnson-Weaver, Herman F. Staats, Herman F. Staats, Herman F. Staats, A. Wesley Burks, A. Wesley Burks, Michael D. Kulis, Michael D. Kulis   +7 more
doaj   +1 more source

Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy

Frontiers in Immunology, 2020
IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening ...
Ann-Marie Malby Schoos, Ann-Marie Malby Schoos, Dominique Bullens, Dominique Bullens, Bo Lund Chawes, Joana Costa, Liselot De Vlieger, Audrey DunnGalvin, Audrey DunnGalvin, Michelle M. Epstein, Johan Garssen, Johan Garssen, Christiane Hilger, Karen Knipping, Karen Knipping, Annette Kuehn, Dragan Mijakoski, Dragan Mijakoski, Daniel Munblit, Daniel Munblit, Nikita A. Nekliudov, Cevdet Ozdemir, Cevdet Ozdemir, Karine Patient, Diego Peroni, Sasho Stoleski, Sasho Stoleski, Eva Stylianou, Mirjana Tukalj, Mirjana Tukalj, Mirjana Tukalj, Kitty Verhoeckx, Mihaela Zidarn, Willem van de Veen, Willem van de Veen   +34 more
doaj   +1 more source

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells [PDF]

, 2016
Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease.
A Johnston, A Kaczmarek, A Nast, A Nayak, A Roers, A Saxena, A Walter, A Yoshizaki, B Flutter, C Loh, C Mauri, C Scholz, E Hobeika, E Serfling, E Soutoglou, EC Rosser, EF Wagner, F Berberich-Siebelt, GJ Martinez, GK Perera, H Blumberg, H Li, H Vinter, H Vinter, HB Schonthaler, J Mehta, J Rengarajan, J Skrzeczynska-Moncznik, K Asadullah, K Guilloteau, K Miles, K Muhammad, K Yanaba, K Yanaba, K Yanaba, KE Kolodziej, L Dietz, M Dannappel, M Gilliet, M Hock, M Matsumoto, M Pasparakis, M Yang, MA Lowes, MC Bonnet, MP Schon, MP Schon, PA Blair, PG Hogan, PJ Hampton, PJ Mease, R Lande, R Weinlich, S Benoit, S Bhattacharyya, S Chuvpilo, S McManus, S Tenzer, T Nojima, U Distler, VC Kyttaris, WI Al-Daraji, WI Al-Daraji   +62 more
core   +2 more sources

Emerging Frontiers in Food Allergy Treatment: Progress, Challenges, and Prospects

Food Frontiers, Volume 6, Issue 6, Page 2789-2822, November 2025.
Food allergy is a rising global health concern with limited treatment options beyond allergen avoidance and emergency care. This review explores the evolving therapeutic landscape, highlighting advances in allergen immunotherapy, biologics such as monoclonal antibodies, and emerging vaccine‐based approaches.
Ayesha Zahid, Hazrat Ismail, Madiha Ajaz, Abdul Qadeer   +3 more
wiley   +1 more source

Pragmatic Low‐Dose Oral Immunotherapy for Preschool Children With Peanut Allergy: A Randomised Controlled Trial

Clinical &Experimental Allergy, Volume 55, Issue 11, Page 1093-1104, November 2025.
This randomised controlled trial of peanut oral immunotherapy (pOIT) in preschool children found that 12 months of low dose pOIT was effective at inducing desensitisation in 74% of children receiving pOIT (vs 11% of children avoiding peanut) and was associated with better quality of life than avoidance.
Michael O'Sullivan, Rachael Wallace, Samantha Thomas, Alyssa Godfrey, Natasha Bear, Bhaumik Mevavala, Sarah Miller, Ingrid Roche, Samara Baldwin, Jessica R. Metcalfe   +9 more
wiley   +1 more source

IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy. [PDF]

, 2013
IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting the protective T regulatory cells in allergic asthma. TH17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced ...
Finotto, S., Graser, A., Koch, S., Lehr, H.A., Mousset, S., Reinhardt, C., Reppert, S., Rieker, R., Ubel, C., Zimmermann, T.   +9 more
core   +2 more sources

Oral and Skin Sensitisation to Peanut Show Different Immunological Features in Brown Norway Rats

Scandinavian Journal of Immunology, Volume 102, Issue 5, November 2025.
Immunological features differ between oral and skin sensitisation, with oral and skin sensitisation driving the development of IgE to different major allergens in peanut, which could pave the way for determining the sensitisation route in patients. Further, oral and skin sensitisation promote different immunological responses in the intestine, which ...
Tiffany K. S. Sztuk, Jeppe M. Larsen, Neil M. Rigby, Anne‐Sofie R. Ballegaard, Irina Pozdnyakova, Stef J. Koppelman, Alan R. Mackie, Katrine L. Bøgh   +7 more
wiley   +1 more source

Food Allergen Immunotherapy in the Treatment of Patients with IgE-Mediated Food Allergy

Medicina
The prevalence of allergic diseases, including food allergy, is increasing, especially in developed countries. Implementation of an elimination diet is not a sufficient therapeutic strategy in patients with food allergy, whose quality of life is ...
Mirjana Turkalj, Adrijana Miletić Gospić, Ivona Višekruna Džidić, Ivana Banić   +3 more
doaj   +1 more source

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy

Allergy, Volume 80, Issue 10, Page 2824-2836, October 2025.
We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg‐derived IL‐10 is important for controlling EoE, but that Breg expansion and function are impaired in this condition. We identify IFNγ as a key negative regulator of Breg function in mice and patients with EoE. Bregs, regulatory B
Rachel L. Clement, Julie Dilollo, Eric M. Rodríguez‐López, Cleandre M. Guerrier, David A. Hill   +4 more
wiley   +1 more source

New modalities of allergen immunotherapy

Human Vaccines & Immunotherapeutics, 2018
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and ...
Manish Ramesh, Merhunisa Karagic
doaj   +1 more source