Results 91 to 100 of about 658,413 (361)

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]

, 2011
Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L., Bartlett D. W., Blessing T., Boeckle S., Boussif O., Carboni B., Carlin C. R., Choi J. S., Christian Dohmen, Davis M. E., Davis M. E., de Bruin K., Ernst Wagner, Esfand R., Haijun Yu, Hua C., Iyer J., Kannan R. M., Kataoka K., Kircheis R., Kircheis R., Kloeckner J., Kloeckner J., Kursa M., Lee J. W., Li S. D., Luo D., Lutz J. F., Maeda H., Maiti P. K., Meyer M., Navarro G., Nie Y., Ogris M., Plank C., Plank C., Russ V., Russ V., Russ V., Schaffert D., Shir A., Simoes S., Svenson S., Tomalia D. A., Tomalia D. A., von Gersdorff K., Wagner E., Wagner E., Walker G. F., Wolschek M. F., Wood K. C., Yellepeddi V. K., Yu H., Yu H., Yu Nie, Yunqiu Li, Zhang X. Q., Zhao X., Zou S. M., Zugates G. T.   +59 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Epidermal Growth Factor and Transforming Growth Factor-α Stimulate the Proliferation of Mouse Uterine Stromal Cells [PDF]

, 2003
Growth factors produced in the uterine endometrium are considered to be involved in the proliferation of the mouse uterine stromal cells induced by estradiol-17beta (E-2) and progesterone (P).
Komatsu, Noriko, Maekawa, Tetsuya, Takahashi, Sumio, Takeuchi, Sakae   +3 more
core   +1 more source

Epidermal Growth Factor Receptor Pathway [PDF]

Journal of Thoracic Oncology, 2010
The epidermal growth factor receptor (EGFR) pathway has provided a new therapeutic target in non-small cell lung cancer (NSCLC). Two EGFR tyrosine kinase inhibitors (TKIs) are being used globally as systemic treatment in advanced NSCLC. In addition, clinical observations with EGFR TKIS led to the discovery of EGFR activating mutations, which has ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Epidermal Growth Factor Expression in Middle Ear Cholesteatoma

Kaohsiung Journal of Medical Sciences, 2004
Middle ear cholesteatoma is destructive to auditory ossicles and temporal bone, and treatment usually requires surgical removal of all epithelial content.
Hung-Pin Chi, Kuen-Yao Ho, Chih-Feng Ta, Ling-Feng Wang, Ka-Wo Lee, Wen-Rei Kuo   +5 more
doaj   +1 more source

S49 Hepatocyte growth factor and epidermal growth factor signalling crosstalk is involved in tunneling nanotube formation in A549 human lung adenocarcinoma cells [PDF]

, 2023
Souvik Banerjee, Griselda Awanis, R. E. Johnson, Stefan Bidula, Derek Warren, Anastasia Sobolewski   +5 more
openalex   +1 more source