Results 71 to 80 of about 410,903 (309)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]

, 2010
Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C Walker, Kirkwood, L.A., Lisa A Kirkwood, Dawn C. Walker, Georgopoulos, N.T., Lisa A. Kirkwood, Kirkwood Lisa A., Jennifer Southgate, Georgopoulos, Nikolaos T., Walker, Dawn C., Walker, D.C., Georgopoulos Nikolaos T., Nikolaos T. Georgopoulos, Kirkwood, Lisa A., Southgate, Jennifer, Southgate, J., Southgate Jennifer, Nikolaos T Georgopoulos, Walker Dawn C.   +18 more
core   +1 more source

Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor–negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus

Journal of International Medical Research
Background Neural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults.
Qingqing Rao, Yuan Cheng, Shuling Yue, Haiying Song, Wangyang Li, Dongli Qi, Qijun Wan   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Analysis of Epithelial Growth Factor-Receptor (EGFR) Phosphorylation in Uterine Smooth Muscle Tumors [PDF]

, 2013
Uterine fibroids are the commonest uterine benign tumors. A potential mechanism of malignant transformation from leiomyomas to leiomyosarcomas has beendescribed.
Darius Dian, Antonis Makrigiannakis, Jeschke, Udo, Klaus Friese, Weissenbacher, Tobias, Mayr, Doris, David Roeder, Udo Jeschke, Nina Ditsch, Thomas Vrekoussis, Tobias Weissenbacher, Vrekoussis, Thomas, Dian, Darius, Ditsch, Nina, Friese, Klaus, Doris Mayr, Makrigiannakis, Antonis, Roeder, David   +17 more
core   +1 more source

EGFL7 participates in regulating biological behavior of growth hormone–secreting pituitary adenomas via Notch2/DLL3 signaling pathway

Tumor Biology, 2017
Growth hormone–secreting pituitary adenoma accounts for about 20% of the third most common intracranial neoplasm—pituitary adenomas—which makes up 15% of all intracranial tumors.
Jianpeng Wang, Qian Liu, Hua Gao, Dehong Wan, Chuzhong Li, Zhaojian Li, Yazhuo Zhang   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum Disorders (ASDs)

, 2014
Background One in 88 children in the US is thought to have one of the autism spectrum disorders (ASDs). ASDs are characterized by social impairments and communication problems.
Anthony J. Russo
core   +1 more source

Serum epidermal growth factor concentrations in healthy men

Revista Cubana de Medicina Militar
Introduction: Despite the documented importance of epidermal growth factor in health, tiny information is available on its serum concentrations. Objective: To describe the behaviour of serum epidermal growth factor.
Héctor José Pérez Hernández, Danay Saavedra Hernández, Tania Crombet Ramos   +2 more
doaj