Results 41 to 50 of about 648,509 (314)

Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium [PDF]

, 2014
Breast cancer risk factors and clinical outcomes vary by tumour marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need for high throughput, standardized
Ali, H Raza, Benitez, Javier, Blomqvist, Carl, Blows, Fiona M, Bolla, Manjeet K, Brinton, Louise, Brock, Ian W, Broeks, Annegien, Brook, Mark N, Caldas, Carlos, Couch, Fergus J, Coulson, Penny, Cox, Angela, Cross, Simon S, Daley, Frances, Dawson, Sarah-Jane, Devillee, Peter, Easton, Douglas F, Fagerholm, Rainer, Figueroa, Jonine, García-Closas, Montserrat, Gazinska, Patrycja, Heikkilä, Päivi, Hollestelle, Antoinette, Howat, William J, Johnson, Nicola, Jones, Louise, Kataja, Vesa, Kosma, Veli-Matti, Lissowska, Jolanta, Mannermaa, Arto, McDuffus, Leigh-Anne, Menéndez, Primitiva, Mesker, Wilma E, Miller, Jodi, Morris, Lorna, Nevanlinna, Heli, Olson, Janet E, Perez, Jose Ignacio Arias, Pharoah, Paul D, Pinder, Sarah, Provenzano, Elena, Reed, Malcolm W, Sanders, Joyce, Sawyer, Elinor J, Schmidt, Marjanka K, Seyaneve, Caroline M, Sherman, Mark E, Sironen, Reijo, van Deurzen, Carolien H M, Visscher, Daniel, Wesseling, Jelle   +51 more
core   +6 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Resistance mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors in non‐small cell lung cancer patients: A meta‐analysis

Thoracic Cancer, 2021
Background Differences in the resistance mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors in patients with non‐small cell lung cancer (NSCLC) harboring epidermal growth factor receptor mutations are unknown.
Nobuaki Kobayashi, Seigo Katakura, Chisato Kamimaki, Kohei Somekawa, Nobuhiko Fukuda, Katsushi Tanaka, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Hongmei Piao, Takeshi Kaneko   +10 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Epidermal Growth Factor and Intestinal Barrier Function

Mediators of Inflammation, 2016
Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation.
Xiaopeng Tang, Hu Liu, Shufen Yang, Zuohua Li, Jinfeng Zhong, Rejun Fang   +5 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors [PDF]

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
A Brar, A Samalecos, A Stavreus-Evers, AA Brahmbhatt, Ana-Maria Bamberger, Anja Wolf, Annemarie Samalecos, AT Fazleabas, B Cloke, B Gellersen, B Gellersen, BA Lessey, Birgit Gellersen, C Ferretti, C Fischer, C Gaggioli, Charlotte H. E. Weimar, CHE Weimar, CM Boomsma, CP Thomas, D Gentilini, D Gentilini, D Haouzi, DE Clark, EE Sander, ER Norwitz, F Chang, F Llorens, F Lyall, G Gaus, G Teklenburg, G Teklenburg, GE Lash, GE Lash, GJ Burton, H Funayama, H Matsumoto, H Xie, HJ Lim, HJ Yoo, I Ihnatovych, IY Yotova, J Anacker, J Baulida, J Fiedler, JJ Brosens, JJ Brosens, JW Tullai, JX Zhu, K Chobotova, K Kawada, K Red-Horse, K Roepstorff, LA Salamonsen, M Bilban, M Bilban, M Cohen, M Gonzalez, M Knöfler, M Knöfler, M Salker, Maren Schwenke, Martin Knöfler, Meijing Wang, Michelle Kruse, MW Maijenburg, Nick S. Macklon, NJ Hannan, NJ Hannan, P Burke, P Jessmon, P Jessmon, P Kaufmann, Philipp Velicky, R Apps, RE Leach, RE Leach, RE Leach, RJ Petrie, RL Kendall, RN Popovici, S Grewal, S Grewal, SK Mitra, Y Jiang, Y Yamazaki   +85 more
core   +7 more sources

Serum Epidermal Growth Factor in Cancer Breast

Journal of High Institute of Public Health, 2007
Several prognostic factors are evaluated in the breast carcinoma and there is a need for new markers for better discrimination of the biologic differences in the primary tumor.
El-Attar HA, Moghazy TF, Fadaly GA, Abou Diba MI   +3 more
doaj   +1 more source

Dynamic tracing for epidermal growth factor receptor mutations in urinary circulating DNA in gastric cancer patients

Tumor Biology, 2017
The mutations of epidermal growth factor receptor are detected in gastric cancer, indicating its suitability as a target for receptor tyrosine kinase inhibitors, as well as a marker for clinical outcome of chemotherapeutic treatments. However, extraction
Xiu-Qin Shi, Wen-Hua Xue, Song-Feng Zhao, Xiao-Jian Zhang, Wukong Sun   +4 more
doaj   +1 more source

A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma

SAGE Open Medical Case Reports, 2023
A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of >7.0 cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left ...
Sosuke Matsumura, Satoshi Ano, Norihiro Kikuchi, Michiko Masuda, Hajime Osawa, Yuzuru Kondo, Yukio Ishii, Nobuyuki Hizawa   +7 more
doaj   +1 more source