Results 41 to 50 of about 301,694 (162)

Targeting the epidermal growth factor receptor [PDF]

British Journal of Cancer, 2004
The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptors (RTK). The EGFR is involved in cell proliferation, metastasis and angiogenesis, and is expressed in a large proportion of epithelial tumours. The two main classes of EGFR inhibitors in clinical trials are the RTK inhibitors and the monoclonal ...
Bassel F. El-Rayes, Patricia LoRusso
openaire   +3 more sources

Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. [PDF]

, 1984
Plasma membranes derived from NR-6 cells, a variant line of Swiss mouse 3T3 cells that does not have cell surface receptors for epidermal growth factor (EGF), inhibited EGF-induced stimulation of DNA synthesis by 50% in serum-starved, subconfluent 3T3 ...
Fox, CF, Matiuck, NV, Peterson, SW, Vale, RD   +3 more
core  

Epidermal Growth Factor Receptor Pathway [PDF]

Journal of Thoracic Oncology, 2010
The epidermal growth factor receptor (EGFR) pathway has provided a new therapeutic target in non-small cell lung cancer (NSCLC). Two EGFR tyrosine kinase inhibitors (TKIs) are being used globally as systemic treatment in advanced NSCLC. In addition, clinical observations with EGFR TKIS led to the discovery of EGFR activating mutations, which has ...
openaire   +3 more sources

The Molecular Perspective: Epidermal Growth Factor [PDF]

The Oncologist, 2003
Abstract Learning Objectives After completing this course, the reader will be able to: Describe the structure and function of epidermal growth factor and its role in cancer development and treatment.
openaire   +4 more sources

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Amelie Gormand, B Schoeberl, BN Kholodenko, BR Voldborg, C Dong, CJ Wikstrand, CY Huang, David R Gilbert, DK Moscatello, E Douville, FA Brightman, GEP Box, H Davies, HS Huang, J Pinney, JE Ferrell Jr, JL Bos, JS Oliveira, KS Brown, L Gao, M Calder, M Hucka, MH Schmidt, Michiel E Adriaens, N Chabrier, Oliver E Sturm, PA Humphrey, PA Humphrey, RD York, Richard J Orton, RJ Orton, RJ Orton, S Corbalan-Garcia, S Hoops, S Kao, S Sasagawa, S Traverse, S Traverse, S Yoon, SB Waters, SD Santos, SH Bigner, TA Libermann, V De Falco, Walter Kolch, WJ Langlois, WR Burack, YH Xu, YR Chen   +48 more
core   +3 more sources

Effects of rapamycin on cultured hepatocyte proliferation and gene expression [PDF]

, 1992
Rapamycin, a potent immunosuppressive drug that disrupts normal signal‐transduction processes, inhibited hepatocyte proliferation without evidence of inherent cytotoxicity in rat hepatocytes cultured in conventional medium or in a medium enriched with ...
Azzarone, A, Carr, BI, Carrieri, G, Francavilla, A, Starzl, TE, Zeng, Q‐   +5 more
core   +1 more source

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]

, 2011
Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L., Bartlett D. W., Blessing T., Boeckle S., Boussif O., Carboni B., Carlin C. R., Choi J. S., Christian Dohmen, Davis M. E., Davis M. E., de Bruin K., Ernst Wagner, Esfand R., Haijun Yu, Hua C., Iyer J., Kannan R. M., Kataoka K., Kircheis R., Kircheis R., Kloeckner J., Kloeckner J., Kursa M., Lee J. W., Li S. D., Luo D., Lutz J. F., Maeda H., Maiti P. K., Meyer M., Navarro G., Nie Y., Ogris M., Plank C., Plank C., Russ V., Russ V., Russ V., Schaffert D., Shir A., Simoes S., Svenson S., Tomalia D. A., Tomalia D. A., von Gersdorff K., Wagner E., Wagner E., Walker G. F., Wolschek M. F., Wood K. C., Yellepeddi V. K., Yu H., Yu H., Yu Nie, Yunqiu Li, Zhang X. Q., Zhao X., Zou S. M., Zugates G. T.   +59 more
core   +1 more source

Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. [PDF]

, 2001
Signaling through growth factor receptors controls such diverse cell functions as proliferation, migration, and differentiation. A critical question has been how the activation of these receptors is regulated.
Banerjee, P, Griffith, L, Johnson, Terry, Mayes, A, Swindle, C, Tran, K, Wells, A   +6 more
core   +3 more sources

Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor [PDF]

, 1997
The major determinants of receptor tissue tyrosine kinase (RTK) signaling specificity have been proposed to be Src homology 2 (SH2) binding sites, phosphotyrosine-containing oligopeptides in the cytoplasmic domain of the receptor.
Lesa, Giovanni M., Sternberg, Paul W.
core  

O-GlcNAcylation of the human epidermal growth factor receptor [PDF]

, 2015
The reversible O-linked attachment of single β-D-N-acetylglucosamine (GlcNAc) moieties to serine/threonine residues in target proteins is a frequently occurring post-translational modification affecting the functionality of many cellular systems. In this
Stateva, Silvia R., Villalobo, Antonio
core   +2 more sources