A comprehensive pathway map of epidermal growth factor receptor signaling
Molecular Systems Biology, 2005 The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells.
Kanae Oda +3 more
semanticscholar +1 more source
Algorithmic and Complexity Results for Decompositions of Biological Networks into Monotone Subsystems [PDF]
arXiv, 2005 A useful approach to the mathematical analysis of large-scale biological networks is based upon their decompositions into monotone dynamical systems. This paper deals with two computational problems associated to finding decompositions which are optimal in an appropriate sense. In graph-theoretic language, the problems can be recast in terms of maximal
arxiv
Gastric luminal epidermal growth factor is affected by diet [PDF]
, 2016 Objective. Diet is an area of major interest to those investigating the causes of cancer of the oesophagus in the Transkei. This study looked at the associations between intragastric epidermal growth factor level, diet and intragastric pH.Setting and ...
Awotedu, KO +3 more
core +1 more source
Different response to epidermal growth factor of hepatocytes in cultures isolated from male or female rat liver. Inhibitor effect of estrogen on binding and mitogenic effect of epidermal growth factor [PDF]
, 1987 Deoxyribonucleic acid (DNA) synthesis in hepatocytes isolated from the livers of male and female rats has been compared in monolayer culture. Plating efficiency, DNA and protein content, viability, and morphologic appearance were the same in cultures ...
Coetzee, M +8 more
core +1 more source
Intranasal epidermal growth factor treatment rescues neonatal brain injury
Nature, 2013 There are no clinically relevant treatments available that improve function in the growing population of very preterm infants (less than 32 weeks’ gestation) with neonatal brain injury.
J. Scafidi +12 more
semanticscholar +1 more source
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer [PDF]
arXiv, 2006 Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cell's phenotypic decision to either proliferate or to migrate at a given point in time. Here, we present a novel three-dimensional multiscale agent-based model to simulate this
arxiv
NGF-response of EGF-dependent progenitor cells obtained from human sympathetic ganglia [PDF]
, 1994 SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympathetic chain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve ...
Ampietro, A. +6 more
core +1 more source
Advances in wound care, 2013 SIGNIFICANCE Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound healing has included the use of EGF. In
R. Bodnar
semanticscholar +1 more source
MAPK Cascades as Feedback Amplifiers [PDF]
arXiv, 2007 Interconvertible enzyme cascades, exemplified by the mitogen activated protein kinase (MAPK) cascade, are a frequent mechanism in signal transduction pathways. There has been much speculation as to the role of these pathways, and how their structure is related to their function.
arxiv
Novel role for amphiregulin in protection from liver injury [PDF]
, 2005 Clinically, the Fas and Fas ligand system plays a central role in the development of hepatocyte apoptosis, a process contributing to a broad spectrum of liver diseases.
Avila, M.A. (Matías Antonio) +7 more
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