Results 81 to 90 of about 822,308 (398)

Novel role for amphiregulin in protection from liver injury [PDF]

, 2005
Clinically, the Fas and Fas ligand system plays a central role in the development of hepatocyte apoptosis, a process contributing to a broad spectrum of liver diseases.
Avila, M.A. (Matías Antonio), Berasain, C. (Carmen), Castillo, J. (Josefa), Erroba, E. (Elena), Lee, D.C. (David C.), Prieto, J. (Jesús), Ruiz Garcia-Trevijano, E. (Elena), Santamaria, M. (Mónica)   +7 more
core  

Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone [PDF]

, 2016
Melatonin, secreted mainly by the pineal gland, plays roles in various physiological functions including protecting cell death. We showed in previous study that the proliferation and differentiation of precursor cells from the adult mouse subventricular ...
Ekthuwapranee, Kasima, Govitrapong, Piyarat, Sotthibundhu, Areechun   +2 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins [PDF]

, 2011
No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target.
Ackerman, Amos, Bao, Ben-Kasus, Benjamin J. Hackel, Biscardi, Bonner, Burgess, Chao, Cochran, Countaway, Cunningham, Downward, Ferguson, Forest M. White, French, Friedman, Hackel, Hackel, Herbst, Hoffman, Jason R. Neil, Joslin, K.Dane Wittrup, Kim, Koide, Lee, Li, Messersmith, Morandell, Nicholson, Ogiso, Pedersen, Perera, Pirie, Sharma, Spangler, Tateishi, Winograd-Katz, Wu, Yamauchi, Yarden   +41 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Selective Desensitization of Growth Factor Signaling by Cell Adhesion to Fibronectin [PDF]

, 2007
Cell adhesion to the extracellular matrix is required to execute growth factor (GF)-mediated cell behaviors, such as proliferation. A major underlying mechanism is that cell adhesion enhances GF-mediated intracellular signals, such as extracellular ...
Asthagiri, Anand R., Galownia, Niki C., Gong, Yuan, Kushiro, Keiichiro   +3 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Targeting colorectal cancer with anti-epidermal growth factor receptor antibodies: focus on panitumumab

Therapeutics and Clinical Risk Management, 2008
Daanish Hoda1, George R Simon1, Christopher R Garrett1,21Division of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; 2Current affiliation: Department of Gastrointestinal Oncology, The University of Texas ...
Daanish Hoda, George R Simon, Christopher R Garrett   +2 more
doaj  

Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]

, 2003
Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi, Masui, Tohru, Oomizu, Souichi, Sharma, Seema, Takahashi, Sumio, Takeuchi, Sakae   +5 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source