Results 21 to 30 of about 151,133 (238)

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

eLife, 2017
Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood.
Ajay Mishra, Bénédicte Oulès, Angela Oliveira Pisco, Tony Ly, Kifayathullah Liakath-Ali, Gernot Walko, Priyalakshmi Viswanathan, Matthieu Tihy, Jagdeesh Nijjher, Sara-Jane Dunn, Angus I Lamond, Fiona M Watt   +11 more
doaj   +1 more source

Iron Metabolism of the Skin: Recycling versus Release

Metabolites, 2023
The skin protects the body against exogenous stressors. Its function is partially achieved by the permanent regeneration of the epidermis, which requires high metabolic activity and the shedding of superficial cells, leading to the loss of metabolites ...
Marta Surbek, Supawadee Sukseree, Leopold Eckhart   +2 more
doaj   +1 more source

Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

eLife, 2020
The intermediate filament protein keratin 14 (K14) provides vital structural support in basal keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and dynamics of keratin IFs in skin ...
Yajuan Guo, Catherine J Redmond, Krystynne A Leacock, Margarita V Brovkina, Suyun Ji, Vinod Jaskula-Ranga, Pierre A Coulombe   +6 more
doaj   +1 more source

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice

Molecules, 2020
Positive physiological benefits of several plant oils on the UV-induced photoaging have been reported in some cell lines and model mice, but perilla oil collected from the seeds of Perilla frutescens L. has not been investigated in this context. To study
Hyeon Jun Choi, Bo Ram Song, Ji Eun Kim, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Hee Seob Lee, Chung Yeoul Lee, Bae-Hwan Kim, Dae Youn Hwang   +10 more
doaj   +1 more source

A Histological Study of the Skin of the Dorsal and Ventral Areas of the Flounder Boleophthalmus dussumieri (Teleostei: Oxudercidae) in Khor Musa (Northwest of the Persian Gulf) [PDF]

تاکسونومی و بیوسیستماتیک, 2022
Mudskippers are members of the Oxudercidae family and are amphibious fishes that are able to spend long periods out of water. In the present study, Boleophthalmus dussumieri was sampled from Petroshimi and Jafari stations.
Fahime Saberi, Ahmad Gharzi, Ashraf Jazayeri, Vahid Akmali, Khosro Chehri   +4 more
doaj   +1 more source

Glucosylceramide synthase activity in murine epidermis: quantitation, localization, regulation, and requirement for barrier homeostasis

Journal of Lipid Research, 1998
Ceramides, which derive from the hydrolysis of glucosylceramide (GlcCer), are the predominant lipid species in the stratum corneum and are critical for epidermal permeability barrier homeostasis. UDP-glucose:ceramide glucosyltransferase (GlcCer synthase)
Chujor S.N. Chujor, Kenneth R. Feingold, Peter M. Elias, Walter M. Holleran   +3 more
doaj   +1 more source

Photoablation at single cell resolution and its application in the Drosophila epidermis and peripheral nervous system

Frontiers in Physiology, 2023
Tissues contain diverse cell populations that, together, make up physiologically functional units. A remarkable example is the animal epidermis, where neuronal and non-neuronal cells intermingle to allow somatosensory perception.
Federica Mangione, Rocco D’Antuono, Nicolas Tapon   +2 more
doaj   +1 more source

GJB4 variants linked to skin disease exhibit a trafficking deficiency en route to gap junction formation that can be restored by co-expression of select connexins

Frontiers in Cell and Developmental Biology, 2023
Epidermal keratinocytes are enriched with at least nine connexins that are key regulators of epidermal homeostasis. The role of Cx30.3 in keratinocytes and epidermal health became evident when fourteen autosomal dominant mutations in the Cx30.3-encoding ...
Sergiu A. Lucaciu, Sergiu A. Lucaciu, Rhett Figliuzzi, Ruth Neumann, Samina Nazarali, Luigi Del Sordo, Luigi Del Sordo, Stephanie E. Leighton, Alexandra Hauser, Qing Shao, Danielle Johnston, Donglin Bai, Dale W. Laird, Dale W. Laird   +13 more
doaj   +1 more source

Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension

Medicina, 2020
Background and objectives: Skin grafting is a method usually used in reconstructive surgery to accelerate skin regeneration. This method results frequently in unexpected scar formations. We previously showed that cutaneous wound-healing in normal mice is
Shiro Jimi, Satoshi Takagi, Francesco De Francesco, Motoyasu Miyazaki, Arman Saparov   +4 more
doaj   +1 more source

The Biology of Varicella-Zoster Virus Replication in the Skin

Viruses, 2022
The replication of varicella-zoster virus (VZV) in skin is critical to its pathogenesis and spread. Primary infection causes chickenpox, which is characterised by centrally distributed skin blistering lesions that are rich in infectious virus.
Cristina Tommasi, Judith Breuer
doaj   +1 more source