Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita [PDF]
Frontiers in Immunology, 2022 Stress-induced heat shock protein 70 (Hsp70) is a key intra- and extracellular molecular chaperone implicated in autoimmune processes. Highly immunogenic extracellular Hsp70 can activate innate and acquired (adaptive) immune responses driving the ...
Stefan Tukaj +6 more
doaj +3 more sources
Luteolin peracetate and gossypolone inhibit immune complex-mediated neutrophil activation in vitro and dermal-epidermal separation in an ex vivo model of epidermolysis bullosa acquisita [PDF]
Frontiers in Immunology, 2023 IntroductionNatural products have been shown to an important source of therapeutics for human disease. In this study, we aimed to identify natural compounds as potential therapeutics for epidermolysis bullosa acquisita (EBA), an autoimmune disease caused
Kai Yang +7 more
doaj +3 more sources
Clinical Features of Paediatric Inflammatory Epidermolysis Bullosa Acquisita: A Case Series Study [PDF]
Acta Dermato-VenereologicaEpidermolysis bullosa acquisita (EBA) rarely develops in childhood. This study retrospectively recruited paediatric patients with EBA (age ≤ 16 years), diagnosed by clinical and histopathological features and results of immunofluorescence, immunoblotting
Yuexin Zhang +5 more
doaj +3 more sources
IgM-mediated epidermolysis bullosa acquisita [PDF]
JAAD Case ReportsSidney Harrison, BS +3 more
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Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita - Brazilian Society of Dermatology [PDF]
Anais Brasileiros de Dermatologia, 2019 : Bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases whose antigenic target is located at the basement membrane zone.
Claudia Giuli Santi +6 more
doaj +3 more sources
Diagnosis of Epidermolysis Bullosa Acquisita: Multicentre Comparison of Different Assays for Serum Anti-type VII Collagen Reactivity [PDF]
Acta Dermato-Venereologica, 2021 Epidermolysis bullosa acquisita is a pemphigoid disease characterized by autoantibodies against type VII collagen. This study compared the sensitivity and specificity of 6 diagnostic assays: type VII collagen non-collagenous domains enzyme-linked ...
Maike M. Holtsche +9 more
doaj +3 more sources
C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita. [PDF]
Front Immunol, 2023 Introduction Inflammatory epidermolysis bullosa acquisita (EBA) is characterized by a neutrophilic response to anti-type VII collagen (COL7) antibodies resulting in the development of skin inflammation and blistering.
Guerrero-Juarez CF +17 more
europepmc +2 more sources
Risk factors and sequelae of epidermolysis bullosa acquisita: A propensity-matched global study in 1,344 patients. [PDF]
Front Immunol, 2022 Identification of risk factors and sequelae of any given disease is of key importance. For common diseases, primary prevention and disease management are based on this knowledge.
Kridin K +5 more
europepmc +2 more sources
The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita. [PDF]
Front Immunol, 2023 Introduction The function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context. Using mice with a global deficiency of C5aR2, we have previously reported an important
Seiler DL +7 more
europepmc +2 more sources
Epidermolysis bullosa acquisita: A report of four cases
Indian Journal of Dermatology, 2022 Abhishek De +4 more
doaj +4 more sources