Results 21 to 30 of about 43,533 (191)

Valproic acid and bladder healing: an experimental study in rats

Revista do Colégio Brasileiro de Cirurgiões, 2022
Purpose: to recognize the effects of valproic acid (VPA), an epigenetic drug, on the bladder healing process, in rats. Method: twenty male Wistar rats were divided in two groups: experimental (A), treated with VPA (150mg/Kg/day), and control (B) with ...
MARIA DE LOURDES PESSOLE BIONDO-SIMÕES, MOACIR OLIVEIRA DALL’ANTONIA, MATHEUS PRINCE GOEHR, RACHEL BIONDO-SIMÕES, SÉRGIO OSSAMU IOSHII, ROGÉRIO RIBEIRO ROBES   +5 more
doaj   +2 more sources

Extending Epigenesis: From Phenotypic Plasticity to the Bio-Cultural Feedback [PDF]

, 2017
The paper aims at proposing an extended notion of epigenesis acknowledging an actual causal import to the phenotypic dimension for the evolutionary diversification of life forms.
A Bouaïchi, A Pascual-Leone, A Petronis, A Probst, A Wagner, AD Goldberg, AP Moczek, B Draganski, B Draganski, B Draganski, B Hrvoj-Mihic, C Dupont, CD Allis, CD Schlichting, CH Darwin, CH Darwin, CH Waddington, CH Waddington, CH Waddington, D Amati, D Bickerton, D Stout, D Stout, D Vazquez-Sanroman, DH Ho, DJ Bolger, DJ Cove, E Jablonka, E Jablonka, E Jablonka, E Saló, EE Hecht, EJ Richards, F Calabrese, F Lui, F Lyco, F Vinckier, G Auletta, G Auletta, G Auletta, G Fusco, G Jobard, G Manzi, G Schlosser, G Tononi, GB Müller, GH Tang, GM Edelman, H Gintis, H Ishibashi, H Vries de, I Colagè, I Colagè, I Colagè, I Colagè, I Colagè, ICG Weaver, ICG Weaver, II Schmalhausen, Ivan Colagè, J Caspers, J Masel, J Sapp, J Sapp, J Varrela, J Varrela, J-P Changeux, JD Yeatman, JK Rilling, JM Whitacre, JP Collins, JW Lewis, K Schick, K Woollett, KD Walton, KN Laland, L Caspers, L Cohen, L Daxinger, L Reich, LV Hooper, LV Hooper, M Heiser, M Iacoboni, M Iacoboni, M Kirschner, M Pigliucci, M Ptashne, M Sato, M Somel, M Szwed, M Thiebaut de Schotten, M Vigneau, MH Johnson, MH Johnson, MJ West-Eberhard, ML Anderson, ML Anderson, ML Anderson, ML Anderson, P D’Ambrosio, P Hammerstein, Paolo D’Ambrosio, PF Ferrari, PH Mason, PS Murray, R Amundson, R Gaillard, R Liebers, RA Waterland, RM Burian, RS Corruccini, S Crawford-Young, S Dehaene, S Dehaene, S Dehaene, S Hihara, S Oyama, SE Sultan, SF Gilbert, SF Gilbert, SF Gilbert, SF Gilbert, SJ Gould, SJ Gould, SJ Gould, SK Mazmanian, SM Rogers, T Adell, TJH Morgan, W Arthur, WC Wimsatt, WW Burggren, Z Petanjek, ZM Saygin   +134 more
core   +3 more sources

Ageing And Cancer As Diseases Of Epigenesis [PDF]

, 2009
Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core   +2 more sources

Evolutionary ecology of the North Atlantic Talitridae (Crustacea, Amphipoda): A review [PDF]

Zoosystematics and Evolution
Four primary estuarine/marine ecotopes recognized in the North Atlantic continental littoral and continental terrestrial margins give rise to the following ecotypes: wrack generalists (=beach-hoppers), psammophilic talitrids (=sandburrowing-hoppers ...
David J. Wildish
doaj   +3 more sources

The Number of Different Binary Functions Generated by NK-Kauffman Networks and the Emergence of Genetic Robustness [PDF]

, 2007
We determine the average number $ \vartheta (N, K) $, of \textit{NK}-Kauffman networks that give rise to the same binary function. We show that, for $ N \gg 1 $, there exists a connectivity critical value $ K_c $ such that $ \vartheta(N,K) \approx e ...
Bechte W., David Romero, de Visser J. A. G. M., Federico Zertuche, Harris B., Kauffman S. A., Kauffman S. A., Kauffman S. A., Kauffman S. A., Lewin B., Romero D., Shymko R. S., Wagner A., Weisbuch G., Winfree A. T.   +14 more
core   +4 more sources

The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution [PDF]

, 2018
Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual ...
Blancke, Stefaan, Braeckman, Johan, De Tiège, Alexis   +2 more
core   +3 more sources

Promoter DNA Methylation Frequency and Clinicopathological Role of miR-129-2 Gene in Patients with Chronic Lymphocytic Leukemia

Oman Medical Journal, 2020
Objectives: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of apparently mature B-type lymphocytes in the lymphohematopoietic organs.
Morteza Hashemi, Mahshid Mohammadipour, Shahrbano Rostami, Mohammad Soleiman Soltanpour   +3 more
doaj   +1 more source

Epigenetic DNA changes and stem cells therapy [PDF]

Archive of Oncology, 2013
We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study ...
Stupar Milanko, Vidović Vitomir, Baltić Vladimir, Štrbac Ljuba, Lukač Dragomir   +4 more
doaj   +1 more source

Quercetin as an Emerging Anti-Melanoma Agent: A four-focus area therapeutic development strategy

Frontiers in Nutrition, 2016
Replacing current refractory treatments for melanoma with new prevention and therapeutic approaches is crucial in order to successfully treat this aggressive cancer form. Melanoma develops from neural crest cells, which express tyrosinase -- a key enzyme
Zoey Harris, Micah G. Donovan, Gisele Morais Branco, Kirsten Limesand, Randy Burd   +4 more
doaj   +1 more source

Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood

Frontiers in Synaptic Neuroscience, 2014
Background: Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals ...
Susan L Andersen, Kai Christian Sonntag
doaj   +1 more source