Results 11 to 20 of about 32,070 (127)

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. No disease‐modifying therapies exist. This review proposes that PD susceptibility begins with epigenetic changes and neuroimmune activity—factors that alter gene expression ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
doaj   +2 more sources

Epigenetic Modulation of IL-7 and IL-10: Toward Personalized Immune Therapies in Viral Epidemics. [PDF]

J Immunol Res
Background Host immune responses, including cytokine production, shape the severity of viral epidemics. Epigenetic mechanisms such as DNA methylation regulate cytokine gene expression and may contribute to immune dysregulation in severe disease. Methods This study analyzed interleukin‐7 (IL‐7), IL‐8, and IL‐10 promoter methylation in 145 COVID‐19 ...
Yulugkural Z, Yildiz M, Topcu E, Elmaslar Mert HT, Temiz A.   +4 more
europepmc   +2 more sources

Epigenetic regulation in lung cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
Role of epigenetics in lung cancer. Epigenetics is considered the main cause of lung cancer. Epigenetics is categorized into three phenomena: histone modification, DNA methylation, and noncoding RNAs. One of the main approaches to controlling lung cancer is early diagnosis.
Shahin Ramazi, Maedeh Dadzadi, Zahra Sahafnejad, Abdollah Allahverdi   +3 more
wiley   +1 more source

The females' response to male attractiveness: Mate choice, larvae production and differential brain protein expression

Ethology, Volume 129, Issue 10, Page 515-526, October 2023., 2023
Our study in Tenebrio molitor employed behavioral and proteomic analyses to establish a correlation between female mate choice and molecular changes in the female brain. We found that females preferred mating with more attractive males, who in turn had a greater likelihood of successfully mating and producing more larvae with attractive males than with
Miguel Hernández‐Villanueva, Sagrario Cordero‐Molina, Constantino Macías García, Jorge Contreras‐Garduño   +3 more
wiley   +1 more source

Valproic acid and bladder healing: an experimental study in rats

Revista do Colégio Brasileiro de Cirurgiões, 2022
Purpose: to recognize the effects of valproic acid (VPA), an epigenetic drug, on the bladder healing process, in rats. Method: twenty male Wistar rats were divided in two groups: experimental (A), treated with VPA (150mg/Kg/day), and control (B) with ...
MARIA DE LOURDES PESSOLE BIONDO-SIMÕES, MOACIR OLIVEIRA DALL’ANTONIA, MATHEUS PRINCE GOEHR, RACHEL BIONDO-SIMÕES, SÉRGIO OSSAMU IOSHII, ROGÉRIO RIBEIRO ROBES   +5 more
doaj   +2 more sources

Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement

Patterns, 2020
Summary: DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide “snapshot” of >450,000 observations (probe ...
Karen Sugden, Eilis J. Hannon, Louise Arseneault, Daniel W. Belsky, David L. Corcoran, Helen L. Fisher, Renate M. Houts, Radhika Kandaswamy, Terrie E. Moffitt, Richie Poulton, Joseph A. Prinz, Line J.H. Rasmussen, Benjamin S. Williams, Chloe C.Y. Wong, Jonathan Mill, Avshalom Caspi   +15 more
doaj   +1 more source

Promoter DNA Methylation Frequency and Clinicopathological Role of miR-129-2 Gene in Patients with Chronic Lymphocytic Leukemia

Oman Medical Journal, 2020
Objectives: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of apparently mature B-type lymphocytes in the lymphohematopoietic organs.
Morteza Hashemi, Mahshid Mohammadipour, Shahrbano Rostami, Mohammad Soleiman Soltanpour   +3 more
doaj   +1 more source

Quercetin as an Emerging Anti-Melanoma Agent: A four-focus area therapeutic development strategy

Frontiers in Nutrition, 2016
Replacing current refractory treatments for melanoma with new prevention and therapeutic approaches is crucial in order to successfully treat this aggressive cancer form. Melanoma develops from neural crest cells, which express tyrosinase -- a key enzyme
Zoey Harris, Micah G. Donovan, Gisele Morais Branco, Kirsten Limesand, Randy Burd   +4 more
doaj   +1 more source

Epigenetic DNA changes and stem cells therapy [PDF]

Archive of Oncology, 2013
We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study ...
Stupar Milanko, Vidović Vitomir, Baltić Vladimir, Štrbac Ljuba, Lukač Dragomir   +4 more
doaj   +1 more source

Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood

Frontiers in Synaptic Neuroscience, 2014
Background: Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals ...
Susan L Andersen, Kai Christian Sonntag
doaj   +1 more source