Results 41 to 50 of about 43,533 (191)
Genes in the postgenomic era [PDF]
We outline three very different concepts of the gene - 'instrumental', 'nominal', and 'postgenomic'. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype ...
B. Alberts+38 more
core +2 more sources
In the world, the scale of development of secondary reservoirs in decompaction rock bodies in a wide formation range is steadily increasing: from the crystalline basement of different ages of various oil and gas-bearing basins to terrigenous deposits ...
O. Yu. Lukin, I. P. Gafych, Ya. V. Lukin
doaj +1 more source
A Regression-based Approach to Robust Estimation and Inference for Genetic Covariance [PDF]
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits, and some variants are shown to be associated with multiple complex traits. Genetic covariance between two traits is defined as the underlying covariance of genetic effects and can be used to measure the shared genetic architecture.
arxiv
ABSTRACT Decades of research have explored how neighborhood conditions relate to child and adolescent health, spawning numerous reviews focused on specific predictors, outcomes, or populations. Less is known about the design and characteristics underpinning this work.
Bria Gresham, Canan Karatekin
wiley +1 more source
Crossovers between epigenesis and epigenetics. A multicenter approach to the history of epigenetics (1901-1975) [PDF]
The origin of epigenetics has been traditionally traced back to Conrad Hal Waddington's foundational work in 1940s. The aim of the present paper is to reveal a hidden history of epigenetics, by means of a multicenter approach.
Costa, R., Frezza, G.
core
Developmental Systems Theory as a Process Theory [PDF]
Griffiths and Russell D. Gray (1994, 1997, 2001) have argued that the fundamental unit of analysis in developmental systems theory should be a process – the life cycle – and not a set of developmental resources and interactions between those resources ...
Griffiths, Paul Edmund, Stotz, Karola
core
ABSTRACT The microbially mediated replacement of sulfate‐bearing evaporites by authigenic carbonate and native sulfur under anoxic conditions is poorly understood. Sulfur‐bearing carbonates from the Monte Palco ridge (Sicily) replacing Messinian gypsum were therefore studied to better characterize the involved microorganisms.
Simon E. Rouwendaal+9 more
wiley +1 more source
Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition, has been documented to increase both health and lifespan across numerous organisms, including humans.
Zoe E. Gillespie+3 more
doaj +1 more source
Comparison of REML methods for the study of phenome-wide genetic variation [PDF]
It is now well documented that genetic covariance between functionally related traits leads to an uneven distribution of genetic variation across multivariate trait combinations, and possibly a large part of phenotype-space that is inaccessible to evolution.
arxiv
Abstract Background There has been substantial progress made across multiple disciplines to emphasize the importance of perinatal mental health both for parents and offspring. This focuses on what has been termed the ‘First 1000 Days’ from conception to the child's second birthday.
Angus MacBeth+6 more
wiley +1 more source