Results 1 to 10 of about 486,968 (249)

Systematic analysis of JmjC gene family and stress­-response expression of KDM5 subfamily genes in Brassica napus [PDF]

PeerJ, 2021
Background Jumonji C (JmjC) proteins exert critical roles in plant development and stress response through the removal of lysine methylation from histones.
Xinghui He, Qianwen Wang, Jiao Pan, Boyu Liu, Ying Ruan, Yong Huang   +5 more
doaj   +2 more sources

CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

Molecular Cancer, 2022
The role of circular RNAs in oncogenesis has begun to be widely studied in recent years, due to the significant impact that these molecules have in disease pathogenesis, as well as their potential for the future of innovative therapies.
Alina Catalina Palcau, Valeria Canu, Sara Donzelli, Sabrina Strano, Claudio Pulito, Giovanni Blandino   +5 more
doaj   +1 more source

The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model

Nature Communications, 2021
Exposure at birth to maternal microbiota has significant effects on offspring health and development. Here, the authors validate a model where inoculation of mice at birth with human vaginal microbiota produces significant effects on offspring health ...
Eldin Jašarević, Elizabeth M. Hill, Patrick J. Kane, Lindsay Rutt, Trevonn Gyles, Lillian Folts, Kylie D. Rock, Christopher D. Howard, Kathleen E. Morrison, Jacques Ravel, Tracy L. Bale   +10 more
doaj   +1 more source

Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

Nature Communications, 2023
BRD4-NUT’s bipartite binding and activation of p300 in NUT carcinoma nucleates a feed-forward spread of histone hyperacetylation and chromatin condensation that sustains aberrant pro-proliferation gene transcription and perpetual tumor cell growth.
Di Yu, Yingying Liang, Claudia Kim, Anbalagan Jaganathan, Donglei Ji, Xinye Han, Xuelan Yang, Yanjie Jia, Ruirui Gu, Chunyu Wang, Qiang Zhang, Ka Lung Cheung, Ming-Ming Zhou, Lei Zeng   +13 more
doaj   +1 more source

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Nature Communications, 2021
22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA ...
Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere   +8 more
doaj   +1 more source

Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos

Nature Communications, 2021
In animal embryos, maternally deposited mRNAs are degraded by several different mechanisms. Here the authors show that C. elegans embryos inherit antisense pool of small RNAs which are loaded into CSR-1 and cleave complementary maternal mRNAs.
Piergiuseppe Quarato, Meetali Singh, Eric Cornes, Blaise Li, Loan Bourdon, Florian Mueller, Celine Didier, Germano Cecere   +7 more
doaj   +1 more source

PPARα in the Epigenetic Driver Seat of NAFLD: New Therapeutic Opportunities for Epigenetic Drugs?

Biomedicines, 2022
Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic and the most common cause of chronic liver disease worldwide. It consists of a spectrum of liver disorders ranging from simple steatosis to NASH which predisposes patients to further fibrosis,
Claudia Theys, Dorien Lauwers, Claudina Perez-Novo, Wim Vanden Berghe   +3 more
doaj   +1 more source

FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

eLife, 2017
Tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. Homozygous TP53 deletion occurs in various types of human cancers for which no therapeutic strategies have yet been reported.
Yichao Fan, Jiao Yue, Mengtao Xiao, Han Han-Zhang, Yao Vickie Wang, Chun Ma, Zhilin Deng, Yingxiang Li, Yanyan Yu, Xinghao Wang, Shen Niu, Youjia Hua, Zhiping Weng, Peter Atadja, En Li, Bin Xiang   +15 more
doaj   +1 more source

Author Correction to: Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
An amendment to this paper has been published and can be accessed via the original article.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source

Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
Background Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source