Results 191 to 200 of about 5,479,707 (298)

Refining the Role of Epigenetic Age Acceleration in Cardiotoxicity Research. [PDF]

JACC CardioOncol
Cao J, Han W, Liu Y.
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

EPIGENETIC and AGING

Yaşlanma; genetik, çevresel ve rastlantısal faktörlerin etkileşimiyle ortaya çıkan, hücresel işlevlerin bozulması ve organizmanın genel performansının azalmasıyla karakterize edilen karmaşık bir süreçtir. Son yıllarda yapılan çalışmalar, epigenetik değişimlerin yaşlanma sürecinde rol oynadığını göstermektedir.
Kizil, Aslıhan, Çetin, Mehmet Emir, Ceylan, Yusuf   +2 more
openaire   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Monocyte epigenetic age acceleration is linked to non-somatic depressive symptoms in women with and without HIV. [PDF]

J Gerontol A Biol Sci Med Sci
Perez NB, Xu K, Xu Y, Lang L, Anastos K, Alcaide ML, Cohen M, Shrestha S, Edmonds A, Meyers J, Kassaye S, Ofotokun I, D'Souza G, Aouizerat B, Rubin LH.   +14 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL). [PDF]

Int J Obes (Lond)
Johnson S, Gonzalez-Mejia J, Aqua JK, Pritchard S, Kaplan R, Cai J, Isasi CR, Perreira KM, Cordero C, Gallo LC, Parada H, Conneely KN, Suglia SF.   +12 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Epigenetic age acceleration in young adults with congenital heart disease. [PDF]

Clin Epigenetics
Jain PN, Zhuang BC, Whitehead J, MacIsaac JL, Dever K, Gahm M, Ermis P, McDade TW, Kobor MS, Checchia PA.   +9 more
europepmc   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source