Animal Models and Experimental Medicine, EarlyView.Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li +7 more
wiley +1 more source
Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers. [PDF]
Clin EpigeneticsHasselholm EB +4 more
europepmc +1 more source
Research progress on biomarkers of traumatic brain injury
Animal Models and Experimental Medicine, EarlyView.Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen +8 more
wiley +1 more source
Exploring causal relationships between epigenetic age acceleration and Alzheimer's disease: a bidirectional Mendelian randomization study. [PDF]
Clin EpigeneticsLiu H, Yin Z, Chen X, Wang Z.
europepmc +1 more source
Equine models in translational medicine: A comparative approach to human health
Animal Models and Experimental Medicine, EarlyView.This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh +1 more
wiley +1 more source
Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects
Animal Models and Experimental Medicine, EarlyView.Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu +12 more
wiley +1 more source
Association between placental epigenetic age acceleration and early postnatal growth patterns. [PDF]
Sci RepPatel P +7 more
europepmc +1 more source
Integrating whole‐bone and regional analyses to understand human scapular growth
The Anatomical Record, EarlyView.Abstract This study investigates ontogenetic changes in human scapular morphology using three‐dimensional geometric morphometrics with whole‐bone and region‐specific analyses. The aim is to evaluate whether the scapula follows a regular developmental pattern and whether its functionally distinct components, the scapular spine (SS) and glenoid fossa ...
Azahara Salazar‐Fernández +3 more
wiley +1 more source
Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study. [PDF]
Front AgingSayer M +6 more
europepmc +1 more source
Animal Research and One Health, EarlyView.This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun +6 more
wiley +1 more source