Results 201 to 210 of about 24,360 (295)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Iron status modulates immune cell proportions to drive epigenetic age acceleration: A 2-step Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu C, Ma T, Cheng X, Zhang F, Zhao C, Yu J.   +5 more
europepmc   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Long-term BMI trajectories and epigenetic age acceleration: the role of genetic risk for obesity. [PDF]

BMC Med
Wen Y, Chen Y, Ma Y, Lu C, Liu Y, Zhang R, Liao J, Wu D, Li C.   +8 more
europepmc   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Epigenetic age acceleration, telomere length, and neurocognitive function in long-term survivors of childhood cancer. [PDF]

Nat Commun
Williams AM, Phillips NS, Dong Q, Ehrhardt MJ, Gilmore N, Loh KP, Meng X, Ness KK, Hudson MM, Robison LL, Wang Z, Krull KR.   +11 more
europepmc   +1 more source

Serum PFAS in Aircraft Rescue and Firefighting (ARFF) Firefighters From Six U.S. Airport Fire Departments

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction Use of aqueous film‐forming foam (AFFF) is a source of exposure to per‐ and polyfluoroalkyl substances (PFAS) for firefighters working in aircraft rescue and firefighting (ARFF) settings. However, data characterizing the association between serum PFAS concentrations and exposure risk factors for ARFF firefighters are limited ...
Miriam M. Calkins, Yiwen Liu, Gavin Horn, Antonia M. Calafat, Judith M. Graber, Shawn C. Beitel, Alberto J. Caban‐Martinez, Julianne Cook Botelho, Randy Krause, Rob Mathis, Jeff Hughes, Casey Grant, Jaclyn M. Goodrich, Amy Nematollahi, Alesia M. Jung, Alissa D. Coleman, Sally Littau, Brooke A. Hawkes, Alexander C. Mayer, Jefferey L. Burgess   +19 more
wiley   +1 more source

Cortisol, DHEAS, and the cortisol/DHEAS ratio as predictors of epigenetic age acceleration. [PDF]

Biogerontology
Takeshita RSC, Nguyen AT, Auger AP, Chung WCJ.   +3 more
europepmc   +1 more source

A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

Epigenetic age acceleration and psychosocial stressors in early childhood. [PDF]

Epigenomics
Mulligan CJ.
europepmc   +1 more source