Results 181 to 190 of about 5,571,062 (272)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Exploring Epigenetic Age Acceleration and Cognitive Change in Middle Adulthood

Background and Objectives: Positive epigenetic age acceleration, in which a person’s biological age is older than their chronological age, is associated with worse cognitive performance.
Daisy V Zavala, John Michael Felt, Christopher Gerald Engeland, Krishna Veeramah, Jennifer Graham-Engeland, Sharon H. Kim, Stacey Scott, Martin Sliwinski, Zita Oravecz, Kristin Bernard   +9 more
core   +1 more source

Monocyte epigenetic age acceleration is linked to non-somatic depressive symptoms in women with and without HIV. [PDF]

J Gerontol A Biol Sci Med Sci
Perez NB, Xu K, Xu Y, Lang L, Anastos K, Alcaide ML, Cohen M, Shrestha S, Edmonds A, Meyers J, Kassaye S, Ofotokun I, D'Souza G, Aouizerat B, Rubin LH.   +14 more
europepmc   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Epigenetic age acceleration as a mechanism underlying increased risks of chronic disease in night shift workers

Background: Understanding the mechanisms underlying the associations between night shift work and increased risks of chronic disease is key to developing effective measures to protect the long-term health of night shift workers.
U, Stephanie Rose
core   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Epigenetic age acceleration and metabolic syndrome among Hispanic/Latino adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL). [PDF]

Int J Obes (Lond)
Johnson S, Gonzalez-Mejia J, Aqua JK, Pritchard S, Kaplan R, Cai J, Isasi CR, Perreira KM, Cordero C, Gallo LC, Parada H, Conneely KN, Suglia SF.   +12 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Epigenetic age acceleration in young adults with congenital heart disease. [PDF]

Clin Epigenetics
Jain PN, Zhuang BC, Whitehead J, MacIsaac JL, Dever K, Gahm M, Ermis P, McDade TW, Kobor MS, Checchia PA.   +9 more
europepmc   +1 more source