Results 101 to 110 of about 14,860 (271)

Epigenetic Clock: A Novel Tool for Nutrition Studies of Healthy Ageing [PDF]

, 2022
Lingxiao He
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

P-529 Epigenetic clock and endometriosis: a new rhythm for reproductive timeline? [PDF]

, 2022
Letizia Li Piani, Marco Reschini, Andrea Busnelli, Gianfranco Fornelli, Paola Viganò, Edgardo Somigliana   +5 more
openalex   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

BMC Medicine
Background Few studies have examined associations between maternal epigenetic age acceleration and adverse birth outcomes, and none have investigated paternal epigenetic age acceleration.
Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg   +10 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Genetic association of the gut microbiota with epigenetic clocks mediated by inflammatory cytokines: a Mendelian randomization analysis

Frontiers in Immunology
BackgroundA new aging biomarker epigenetic clock has been developed. There exists a close link between aging and gut microbiota, which may be mediated by inflammatory cytokines.
Siyu Tian, Xingyu Liao, Siqi Chen, Yu Wu, Min Chen   +4 more
doaj   +1 more source

Additional file 4 of Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

, 2022
James E. Barrett, Chiara Herzog, Yoo‐Na Kim, Thomas E. Bartlett, Allison Jones, Iona Evans, David Cibula, Michal Zikán, Line Bjørge, Nadia Harbeck, Nicoletta Colombo, Sacha J. Howell, Angelique Flöter Rådestad, Kristina Gemzell‐Danielsson, Martin Widschwendter   +14 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging.
Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang, Weixiang Chen   +7 more
doaj   +1 more source