Results 101 to 110 of about 431,319 (321)

Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life [PDF]

, 2017
A balanced interaction between the homeostatic mechanisms of mother and the devel- oping organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal ...
Alcantara-Alonso, Alexander, Arborelius, Bale, Baram, Barker, Bellisario, Benjamin Neelon, Bosch, Bouret, Bowman, Briana, Brummelte, Brunson, Brunton, Brunton, Brunton, Brunton, Capron, Chen, Chen, Choy, Cirulli, Cirulli, Class, Clifton, Cottrell, Dallman, Davis, de Weerth, Demendi, Desai, Dimasuay, Dunkel, D’Amato, Eghbal-Ahmadi, Ehlers, Ellman, Entringer, Fasting, Faturi, Fenoglio, Gao, Gillman, Glynn, Gomez-Roig, Grammatopoulos, Gunnar, Harville, Hollrigel, Husum, Ibanez, Kammerer, Kensara, Korosi, Labonte, Ladyman, Larsen, Lee, Lockwood, Machado, MacKay, Maffeis, Magiakou, Maniam, Marciniak, McLean, Mingrone, Owens, Pasquali, Paternain, Pedersen, Pelleymounter, Peng, Perrone, Pervanidou, Petraglia, Pihoker, Plotsky, Purcell, Robinson, Romens, Sanchez, Sandman, Sandman, Schmidt, Schulte, Seckl, Seckl, Sferruzzi-Perri, Shapiro, Singh-Taylor, Smith, Soma-Pillay, Stout, Suderman, Sun, Symonds, Tamashiro, Turecki, van Bodegom, Vazquez, Vickers, Wadhwa, Wakahashi, Walker, Wang, Weaver, Weaver, Weinstock, Whitaker, Whitehead, Wolfe, Yam, Zambrano   +114 more
core   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Circadian Regulation of Immunity Through Epigenetic Mechanisms

Frontiers in Cellular and Infection Microbiology, 2020
The circadian clock orchestrates daily rhythms in many physiological, behavioral and molecular processes, providing means to anticipate, and adapt to environmental changes.
Ricardo Orozco-Solis, Lorena Aguilar-Arnal   +1 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

, 2020
Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA ...
Alvarez-Dominguez, J., Charlton, J., Donaghey, J., Helman, A., Kenty, J., Meissner, A., Melton, D., Rasouli, N., Straubhaar, J.   +8 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort

Biology, 2022
We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45–69 years ...
Olga Chervova, Elizabeth Chernysheva , Kseniia Panteleeva , Tyas Arum Widayati , Natalie Hrbkova, Jadesada Schneider , Vladimir Maximov , Andrew Ryabikov , Taavi Tillmann , Hynek Pikhart, Martin Bobak , Vitaly Voloshin , Sofia Malyutina , Stephan Beck    +13 more
doaj   +1 more source

Epigenetic Control of Circadian Clock Operation during Development [PDF]

, 2012
The molecular players of circadian clock oscillation have been identified and extensively characterized. The epigenetic mechanisms behind the circadian gene expression control has also been recently studied, although there are still details to be ...
Gong, Changxia, Li, Chengwei, Li, Xiaodong, Wu, Jianguo, Yu, Shuang   +4 more
core   +3 more sources

The Link Between Epigenetic Clocks for Aging and Senescence [PDF]

Frontiers in Genetics, 2019
Published by Frontiers Media ...
Wolfgang Wagner, Wolfgang Wagner
openaire   +5 more sources