Results 121 to 130 of about 14,428 (154)
Some of the next articles are maybe not open access.
Epigenetic Drift, Epigenetic Clocks and Cancer Risk
Epigenomics, 2016It is well-established that the DNA methylation landscape of normal cells undergoes a gradual modification with age, termed as 'epigenetic drift'. Here, we review the current state of knowledge of epigenetic drift and its potential role in cancer etiology.
Shijie C, Zheng +2 more
openaire +2 more sources
Epigenetic Clocks: In Aging-Related and Complex Diseases
Cytogenetic and Genome Research, 2023<b><i>Background:</i></b> There is evidence that complex diseases and mortality are associated with DNA methylation and age acceleration. Numerous epigenetic clocks, including Horvath, Hannum, DNA PhenoAge, DNA GrimAge, and Dunedin Pace of Aging Methylation, continue to be developed in this young scientific field.
Margiotti, Katia +4 more
openaire +2 more sources
This document describes the generation of epigenetic clocks and immune cell counts from DNA methylation data from participants of the National Longitudinal Study of Adolescent to Adult Health (Add Health). It provides detailed definitions, computation methods, data descriptions, and guidance for interpretation to ensure consistent and reproducible use ...
Levitt, Brandt +4 more
openaire +1 more source
Levitt, Brandt +4 more
openaire +1 more source
The Epigenetic Language of Circadian Clocks
2013Epigenetic control, which includes DNA methylation and histone modifications, leads to chromatin remodeling and regulated gene expression. Remodeling of chromatin constitutes a critical interface of transducing signals, such as light or nutrient availability, and how these are interpreted by the cell to generate permissive or silenced states for ...
Saurabh, Sahar, Paolo, Sassone-Corsi
openaire +2 more sources
Epigenetic Aging Clocks in Ecology and Evolution
Trends in Ecology & Evolution, 2019The development of 'epigenetic clocks' is changing how biomedical scientists approach age-associated disease and leads to new insights and questions of wider significance. We highlight recent findings concerning epigenetic aging and discuss their relevance to life history evolution and their potential for advancing the field of ecological and ...
Benjamin B, Parrott, Emily M, Bertucci
openaire +2 more sources
C&EN Global Enterprise, 2019
Epigenetic clocks use DNA methylation to measure biological age. Differences between biological age and actual chronological age can reflect health issues. Such clocks are constructed by measuring DNA methylation at multiple sites and correlating that with the known age.
openaire +1 more source
Epigenetic clocks use DNA methylation to measure biological age. Differences between biological age and actual chronological age can reflect health issues. Such clocks are constructed by measuring DNA methylation at multiple sites and correlating that with the known age.
openaire +1 more source
2017
Background: During the last decade, multiple efforts have been dedicated to the modelling of an accurate predictor of age based on DNA methylation status(1–4). However, most of current models have been trained and therefore predict over a limited typology of tissues, and consequently the application over a wider extent of tissues is restricted .
openaire +1 more source
Background: During the last decade, multiple efforts have been dedicated to the modelling of an accurate predictor of age based on DNA methylation status(1–4). However, most of current models have been trained and therefore predict over a limited typology of tissues, and consequently the application over a wider extent of tissues is restricted .
openaire +1 more source
Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly