Results 191 to 200 of about 317,209 (276)

Epigenetic clocks and aging

Gaceta Médica de México
openaire   +2 more sources

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Epigenetic Clock Analysis of Biological Aging in Adults With Documented Childhood Maltreatment.

JAMA Netw Open
Belsky DW, Bellatin A, Courtney K, Danese A, Indik CE, Graf G, Lapp HE, Ryan CP, Champagne FA, Widom CS.   +9 more
europepmc   +1 more source

Epigenetic age and fertility timeline: testing an epigenetic clock to forecast in vitro fertilization success rate. [PDF]

Reprod Biol Endocrinol
Marinello D, Reschini M, Di Stefano G, Carullo G, Casalechi M, Tarantini L, Albetti B, Bollati V, Viganò P, Somigliana E, Li Piani L.   +10 more
europepmc   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Characterising developmental dynamics of adult epigenetic clock sites. [PDF]

EBioMedicine
Mulder RH, Neumann A, Felix JF, Suderman M, Cecil CAM.   +4 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Decoding disease-specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validation. [PDF]

EBioMedicine
Li P, Zhu J, Wang S, Zhuang H, Zhang S, Huang Z, Cai F, Song Z, Liu Y, Liu W, Freidel S, Wang S, Schwarz E, Chen J.   +13 more
europepmc   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. [PDF]

Nat Aging
Fuentealba M, Rouch L, Guyonnet S, Lemaitre JM, de Souto Barreto P, Vellas B, Andrieu S, Furman D.   +7 more
europepmc   +1 more source