Results 201 to 210 of about 431,319 (321)

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohortsResearch in context

EBioMedicine, 2019
Background: Measures based on DNA methylation, epigenetic clocks, have recently gained attraction as predictors of mortality and age-related pathologies. However, the origins of variation in these measures are not well understood.
Juulia Jylhävä, Jacob Hjelmborg, Mette Soerensen, Elizabeth Munoz, Qihua Tan, Ralf Kuja-Halkola, Jonas Mengel-From, Kaare Christensen, Lene Christiansen, Sara Hägg, Nancy L. Pedersen, Chandra A. Reynolds   +11 more
doaj  

Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts

Clinical Epigenetics
Background Epigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how external exposures during gestation can influence the in-utero environment and subsequent offspring development. Despite the
Wei Q. Deng, Marie Pigeyre, Sandi M. Azab, Samantha L. Wilson, Natalie Campbell, Nathan Cawte, Katherine M. Morrison, Stephanie A. Atkinson, Padmaja Subbarao, Stuart E. Turvey, Theo J. Moraes, Piush Mandhane, Meghan B. Azad, Elinor Simons, Guillaume Pare, Sonia S. Anand   +15 more
doaj   +1 more source

LONGITUDINAL TRAJECTORIES OF EPIGENETIC CLOCKS IN HUMANS AND EFFECTS OF MEDICATION USE [PDF]

, 2019
Sara Hägg
openalex   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Identifying epigenetic aging moderators using the epigenetic pacemaker

Frontiers in Bioinformatics
Epigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration ...
Colin Farrell, Chanyue Hu, Kalsuda Lapborisuth, Kyle Pu, Sagi Snir, Matteo Pellegrini   +5 more
doaj   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Epigenetic Silencing of the Circadian Clock Gene CRY1 is Associated with an Indolent Clinical Course in Chronic Lymphocytic Leukemia

, 2012
Maher Hanoun, Lewin Eisele, Masako Suzuki, John M. Greally, Andreas Hüttmann, Semra Aydin, René Scholtysik, Ludger Klein‐Hitpaß, Ulrich Dührsen, Jan Dürig   +9 more
openalex   +2 more sources

A generalizable epigenetic clock captures aging in two nonhuman primates [PDF]

, 2022
Elisabeth A. Goldman, Kenneth L. Chiou, Marina M. Watowich, Arianne Mercer, Sierra Sams, Julie E. Horvath, Jordan A. Anderson, Jenny Tung, James P. Higham, Lauren J. N. Brent, Melween I. Martínez, Michael J. Montague, Michael L. Platt, Kirstin N. Sterner, Noah Snyder‐Mackler   +14 more
openalex   +1 more source