Results 211 to 220 of about 431,319 (321)

Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

Advanced Materials, EarlyView.
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang, Hengji Zhan, Bolin Pan, Leli Zeng, Zehua Chen, Sen Liu, Qiang Zhang, Xuwei Hong, Junlin Lu, Xinrou Lin, Xiao Zhao, Jiajian Lai, Kaiwen Jie, Ye Li, Jianmei Zhong, Shengmeng Peng, Siting Chen, Changhao Chen, Wenlong Zhong, Shaoxu Wu, Yihang Pan, Tianxin Lin, Xu Chen   +22 more
wiley   +1 more source

P095 Epigenetic clocks have the potential to predict future grip strength in males but not females [PDF]

, 2022
Nicholas R. Fuggle, Leo D. Westbury, Faisal Reswan, Nikki Graham, Negusse Kitaba, Kate A. Ward, Kate A. Ward, Nicholas C. Harvey, John W. Holloway, Elaine Dennison, Cyrus Cooper   +10 more
openalex   +1 more source

CheekAge: a next-generation buccal epigenetic aging clock associated with lifestyle and health

GeroScience
Epigenetic aging clocks are computational models that predict age using DNA methylation information. Initially, first-generation clocks were developed to make predictions using CpGs that change with age.
Maxim N Shokhirev, Nicole S. Torosin, Daniel J. Kramer, Adiv A Johnson, Trinna L Cuellar   +4 more
semanticscholar   +1 more source

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

Advanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş, Mahshid Reshadsedghi, Mustafa Şen, Volkan Kılıç, Nesrin Horzum   +4 more
wiley   +1 more source

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma

, 2021
Paula Restrepo, Adrian Bubie, Amanda J. Craig, Ismaïl Labgaa, Myron Schwartz, Swan N. Thung, Gustavo Stolovitzky, Bojan Losic, Augusto Villanueva   +8 more
openalex   +1 more source

RELATIONSHIP BETWEEN METABOLIC HEALTH AND 5 EPIGENETIC CLOCKS IN THE BERLIN AGING STUDY II (BASE-II) [PDF]

, 2022
Ilja Demuth, Sandra Düzel, Valentin Max Vetter, Johanna Drewelies, Yasmine Sommerer, Elisabeth Steinhagen‐Thiessen, Denis Gerstorf, Lars Bertram   +7 more
openalex   +1 more source

Frequency‐Dependent Demethylation of Cancer DNAs by High‐Power Terahertz Radiation

Advanced Photonics Research, EarlyView.
Effective demethylation of cancer DNA is successfully demonstrated by resonant irradiation with high‐power terahertz (THz) waves at the 10 mW level, combined with metamaterial‐based THz filters. The dependence of spectral filtering on demethylation indicates that the resonant frequency of 1.6 THz of cancer DNAs plays a crucial role in reducing the ...
Chaeyoon Kim, Seung Won Jin, Seong Cheol Lee, Donghak Oh, Soojeong Baek, Bumki Min, Hee‐Jin Yang, Joo‐Hiuk Son, Fabian Rotermund   +8 more
wiley   +1 more source

The Epigenetic and Metabolic Language of the Circadian Clock

, 2016
Paolo Sassone–Corsi
openalex   +1 more source

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, EarlyView.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [PDF]

, 2023
Dalia Halawani, Yiqun Wang, Aarthi Ramakrishnan, Molly Estill, Xijing He, Li Shen, Roland H. Friedel, Hongyan Zou   +7 more
openalex   +1 more source