Results 161 to 170 of about 193,396 (281)

Unraveling the complexity of skin's biological aging utilizing epigenetic clocks. [PDF]

Clin Epigenetics
Bienkowska A, Qi M, Kanta K, Del Pilar Bonilla-Tobar M, Völzke H, Gallinat S, Jaspers S, Clemann S, Winnefeld M, Grönniger E, Kaderali L, Falckenhayn C.   +11 more
europepmc   +1 more source

Clocks-Shi/Code-for-hess-2023-100: Evaporation and sublimation measurement and modeling of an alpine saline lake influenced by freeze–thaw on the Qinghai–Tibet Plateau

<p>The code is the data processing and plotting of the academic paper titled "Evaporation and sublimation measurement and modeling of an alpine saline lake influenced by freeze–thaw on the Qinghai–Tibet Plateau".</p ...
Clocks-Shi
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts. [PDF]

J Neurol Neurosurg Psychiatry
Tang X, Sumra V, Sato C, Moreno D, Khodadadi M, Sadia N, Wong C, Colella B, Green REA, Ta J, Blennow K, Zetterberg H, Wennberg R, Tator CH, Zhang M, Rogaeva E, Tartaglia MC.   +16 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Biological Versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response. [PDF]

Aging Cell
Sehgal R, S Borrus D, Gonzalez J, Markov Y, Higgins-Chen A, Alzheimer's Disease Neuroimaging Initiative.   +5 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

DNA methylation quality control decisions, removed beta values, and their influence on epigenetic clocks. [PDF]

Epigenomics
Kelly AL, Levitt B, Aiello A, Martin CL, Harris KM, Gaydosh L.   +5 more
europepmc   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

From the lab to lifestyle: epigenetic clocks in personalized aging and health. [PDF]

Biogerontology
Ibáñez-Cabellos JS, García-Giménez JL, Escobar J, Pallardó FV, Mena-Mollá S.   +4 more
europepmc   +1 more source