Results 161 to 170 of about 307,044 (299)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Resistance training and cardiovascular health: epigenetic regulation. [PDF]

Front Physiol
Silva JG, Rodrigues LF, Torres T, Improta-Caria AC, Oliveira EM, Fernandes T.   +5 more
europepmc   +1 more source

Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings [PDF]

Kerstin Uvnäs‐Moberg, Mechthild M. Groß, Jean Calleja‐Agius, Jonathan D. Turner   +3 more
openalex   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21 st International Symposium on Microsomes and Drug Oxidations (MDO)

, 2019
Hyunyoung Jeong, Li Wang, David J. Waxman, Aadra P. Bhatt, Ulrich M. Zanger, Magnus Ingelman‐Sundberg, Peter J. Turnbaugh, Nathan J. Cherrington, Xiao‐bo Zhong, Matthew R. Redinbo, Wen Xie, Curtis D. Klaassen, Edward T. Morgan, Pengying Hao, Lauren M. Aleksunes, YU Ai-ming   +15 more
openalex   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Editorial: Epigenetic regulation in fibrosis. [PDF]

Front Mol Biosci
Wei Q, Hu X, Sanders Y.
europepmc   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Advances in the diagnosis and treatment of oligoasthenozoospermia based on epigenetic regulation. [PDF]

Ther Adv Urol
Zhao HB, Ba WY, Zhu WB, Wang GZ, Wang ZL, Wang SQ.   +5 more
europepmc   +1 more source

The lemon genome and DNA methylome unveil epigenetic regulation of citric acid biosynthesis during fruit development [PDF]

Hang Yu, Chao Zhang, Chuang Lu, Yana Wang, Congcong Ge, Gui‐Xiang Huang, Haifeng Wang   +6 more
openalex   +1 more source