Results 231 to 240 of about 307,044 (299)

Epigenetic Regulation of Higher-Order Chromatin Structure (HOCS) and Its Implication in Human Diseases. [PDF]

Cancers (Basel)
Ladel L, Sailo B, Das P, Lin ES, Tan WY, Chhoda A, Tang H, Ang-Olson O, He L, John N, Kratz JD, Sharma A, Ahuja N.   +12 more
europepmc   +1 more source

Functional Role for Shear Responsive cis Elements and Fluid Shear Stress in Epigenetic Regulation of Endothelial Nitric Oxide Synthase

, 2014
John Joo Yiul Lee
openalex   +1 more source

Epigenetic regulation of female puberty

, 2014
Alejandro Lomniczi, Hollis Wright, Sergio R. Ojeda   +2 more
openalex   +2 more sources

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases: A Review of Recent Advances and Therapeutic Implications. [PDF]

Int J Mol Sci
Młynarska E, Bojdo K, Bulicz A, Hossa K, Lisińska W, Stasiak P, Rysz J, Franczyk B.   +7 more
europepmc   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Epigenetic regulation of NAFLD: A preclinical study. [PDF]

Indian J Med Res
Giri S, Parasar AK, Kumar V.
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Dissecting the role of epigenetic regulation in oral squamous cell carcinoma microenvironment: mechanisms and therapeutics. [PDF]

Front Immunol
Li X, Ren Y, Pei S, Zhao K, Chen G, He Z.   +5 more
europepmc   +1 more source

Transcriptional and epigenetic regulation of human CD4 T cell cytotoxic function: Molecular study of human cytotoxic CD4 T cells

, 2017
Yasmina Serroukh, Arnaud Marchant
openalex   +1 more source