Results 81 to 90 of about 307,044 (299)

The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential [PDF]

, 2022
Najla Kfoury, Ramachandran Prakasam, Santhi Pondugula, J. S. Lagas, Scot J. Matkovich, Paul Gontarz, Lihua Yang, Hiroko Yano, A. H. Kim, Joshua B. Rubin, Kristen L. Kroll   +10 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Supplementary Table 2 from Genome-wide Profiling of Chromatin Signatures Reveals Epigenetic Regulation of MicroRNA Genes in Colorectal Cancer

, 2023
Hiromu Suzuki, Shintaro Takatsuka, Hirofumi Akashi, Eiichiro Yamamoto, Masanori Nojima, Reo Maruyama, Masahiro Kai, Hiro‐o Yamano, Yasushi Sasaki, Takashi Tokino, Yasuhisa Shinomura, Kohzoh Imai, Minoru Toyota   +12 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Epigenetic regulation in cancer

MedComm
AbstractEpigenetic modifications are defined as heritable changes in gene activity that do not involve changes in the underlying DNA sequence. The oncogenic process is driven by the accumulation of alterations that impact genome's structure and function.
Gu, Minzhi, Ren, Bo, Fang, Yuan, Ren, Jie, Liu, Xiaohong, Wang, Xing, Zhou, Feihan, Xiao, Ruiling, Luo, Xiyuan, You, Lei, Zhao, Yupei   +10 more
openaire   +4 more sources

Supplementary Figure S1 from GKN1–miR-185–DNMT1 Axis Suppresses Gastric Carcinogenesis through Regulation of Epigenetic Alteration and Cell Cycle

, 2023
Jung‐Hwan Yoon, Yoo Jin Choi, Won Suk Choi, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Jung Young Lee, Won Sang Park   +7 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

PB2480: LENTIVIRAL LABELING OF STROMAL LAYER OF LONG-TERM BONE MARROW CULTURE DEMONSTRATED INEFFICIENCY FOR MESENCHYMAL STEM CELLS AND CONTRIBUTION OF NON-STEM CELLS TO HEMATOPOIETIC ECTOPIC FOCUS IN MICE

HemaSphere, 2023
Dmitriy Karpenko, Aleksei Bigildeev
doaj   +1 more source

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57 [PDF]

, 2019
Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger, Anne C. Ferguson‐Smith   +6 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source