Results 241 to 250 of about 475,691 (380)

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Mitoepigenetic Targeting of Age-Related Dysfunction: Mechanisms, Therapeutic Avenues, and Transgenerational Implications. [PDF]

Aging Adv
Neikirk K, Thapliyal S, Masenga SK, Oliver A, Mungai M, Le H, Beasley HK, Marshall AG, Cooper AT, Cheairs TG, Rodriguez BI, Garza-Lopez E, Katti P, Hinton A.   +13 more
europepmc   +1 more source

Epigenetics: A Landscape Takes Shape

Cell, 2007
Aaron D. Goldberg, C. D. Allis, E. Bernstein   +2 more
semanticscholar   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Pharmaco-Epigenetics and Epigenetic Drugs in Type 2 Diabetes: Can Epigenetics Predict Drug Efficiency? [PDF]

Biomedicines
Mkhize SS, Chuturgoon AA, Ghazi T, Machaba KE.   +3 more
europepmc   +1 more source

A change of ploidy can modify epigenetic silencing.

, 1996
Ortrun Mittelsten Scheid, Ludmila Jakovleva, Karin Afsar, Jolanta Małuszyńska, Jerzy Paszkowski   +4 more
openalex   +1 more source

Modulation of EGFR Gene Transcription by a Polymorphic Repetitive Sequence – a Link between Genetics and Epigenetics [PDF]

, 2000
Frank Gebhardt, Horst Bürger, Burkhard Brandt   +2 more
openalex   +1 more source

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

Advanced Healthcare Materials, EarlyView.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source

Global research trends on epigenetics and cancer: A bibliometric analysis. [PDF]

Medicine (Baltimore)
Zhong X, Chen D.
europepmc   +1 more source

Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis

, 1998
Ortrun Mittelsten Scheid, Karin Afsar, Jerzy Paszkowski   +2 more
openalex   +1 more source