Results 151 to 160 of about 89,797 (267)
MedComm – Oncology, Volume 5, Issue 2, June 2026.This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source
Pitfalls and missing links in current understanding of 4D genomes
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley +1 more source
Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini +9 more
wiley +1 more source
Development and validation of MethylCog, a blood DNA methylation proxy for cognition
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea +9 more
wiley +1 more source
Molecular Carcinogenesis, Volume 65, Issue 5, Page 603-614, May 2026.ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao +6 more
wiley +1 more source
The epigenomic landscape of transposable elements across normal human development and anatomy [PDF]
, 2019 Choudhary, Mayank N.K. +3 more
core +1 more source
Maternal Chrono‐Nutrition and Placental DNA Methylation: The BiSC Study
Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.This is the first study to examine how the timing of a mother's meals during pregnancy relates to changes in placental DNA methylation, an epigenetic mark. We found that the timing of the last daily meal was most important. Some epigenetic changes were linked to genes involved in placental function and development, and the long‐term health consequences
Joana Llauradó‐Pont +12 more
wiley +1 more source
The environmentally responsive plant epigenome: insights from jasmonate signaling. [PDF]
New PhytolZander M, Vesper E.
europepmc +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma +12 more
wiley +1 more source
Predicting the effect of CRISPR-Cas9-based epigenome editing. [PDF]
ElifeBatra SS +6 more
europepmc +1 more source