Results 111 to 120 of about 64,265 (410)

Next-Generation Sequencing:Application in Liver Cancer-Past, Present and Future? [PDF]

, 2012
Hepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying ...
Daly, Ding, Guichard, Hawkins, Ho, Huang, Jones, Lee, Ley, Marquardt, McDermott, Meldrum, Russnes, Sung, Thomas, Totoki, Woo, Yachida, Zender, Zhang   +19 more
core   +2 more sources

Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury

Advanced Science, EarlyView.
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang   +12 more
wiley   +1 more source

Bayesian Genome- and Epigenome-wide Association Studies with Gene Level Dependence [PDF]

Biometrics 73(3), 1018-1028, 2017, 2016
High-throughput genetic and epigenetic data are often screened for associations with an observed phenotype. For example, one may wish to test hundreds of thousands of genetic variants, or DNA methylation sites, for an association with disease status. These genomic variables can naturally be grouped by the gene they encode, among other criteria. However,
arxiv   +1 more source

Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers

Neoplasia: An International Journal for Oncology Research, 2005
The role of promoter methylation in the process of cancer cell metastasis has not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor, follistatin domain) gene was reported in human colon, gastric,
Matthias P.A. Ebert, Suzanne H. Mooney, Lori Tonnes-Priddy, Joe Lograsso, Juliane Hoffmann, Jie Chent, Christoph Rocken, Hans-Ulrich Schulz, Peter Malfertheiner, Catherine Lofton-Day   +9 more
doaj   +1 more source

A convolutional neural network-based regression model to infer the epigenetic crosstalk responsible for CG methylation patterns

BMC Bioinformatics, 2021
Background Epigenetic modifications, including CG methylation (a major form of DNA methylation) and histone modifications, interact with each other to shape their genomic distribution patterns.
Wan Kin Au Yeung, Osamu Maruyama, Hiroyuki Sasaki   +2 more
doaj   +1 more source

Deep Learning and Machine Learning Applications in Biomedicine

Applied Sciences, 2023
The rise of omics research, spanning genomics, transcriptomics, proteomics, and epigenomics, has revolutionized our understanding of biological systems [...]
Peiyi Yan, Yaojia Liu, Yuran Jia, Tianyi Zhao   +3 more
doaj   +1 more source

Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. [PDF]

, 2018
During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to identify enhancers involved in the initial events of cardiogenesis, which occurs during the ...
Bruneau, Benoit G, Devine, Patrick, Scott, Ian C, Song, Mengyi, Wilson, Michael D, Yuan, Xuefei   +5 more
core   +3 more sources

Ethical Issues in Research and Development of Epigenome-wide Technologies [PDF]

, 2020
To date, few scholarly discussions on ethical implications of epigenetics and epigenomics technologies have focused on the current phase of research and development, in which researchers are confronted with real and practical ethical dilemmas.
Bolt, L.L.E. (Ineke), Bunnik, E.M. (Eline), Timmers, M. (Marjolein)   +2 more
core   +2 more sources

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source