Results 151 to 160 of about 43,487 (351)

CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features [PDF]

open access: hybrid, 2009
Kobby Essien   +5 more
openalex   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

open access: yesGlia, EarlyView.
Multiple sclerosis involves chronic CNS inflammation and neurodegeneration. This review highlights glial cells as key drivers in progressive MS, focusing on lesion pathology, molecular dysfunction, and human‐relevant model systems. ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive ...
Volker Siffrin
wiley   +1 more source

Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development [PDF]

open access: green, 2009
Robert A. Waterland   +12 more
openalex   +1 more source

Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway

open access: yesImmunity & Ageing
Systemic lupus erythematosus (SLE) is an autoimmune disorder that commonly affects the skin, kidneys, joints, and various other systemic tissues, with its development intricately linked to the process of immunosenescence.
Feng Xiong   +10 more
doaj   +1 more source

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez   +2 more
wiley   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano   +6 more
wiley   +1 more source

Epigenomic Modifications Predict Active Promoters and Gene Structure in Toxoplasma gondii

open access: gold, 2007
Mathieu Gissot   +4 more
openalex   +2 more sources

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