Results 151 to 160 of about 27,140 (186)

EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data. [PDF]

Epigenomics
Zhu T, Faragó T, Bollepalli S, Heikkinen A, Hukkanen M, Raitakari O, Lehtimäki T, Korhonen T, Kaprio J, Fang F, Lawrence KG, Sandler DP, Spildrejorde MR, Gervin K, Pan Y, Costeira R, Bell JT, Ollikainen M.   +17 more
europepmc   +1 more source

Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, Volume 20, Issue 3, Page 588-610, March 2026.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

SLUR(M)-py: a SLURM powered Pythonic pipeline for parallel processing of 3D (Epi)genomic profiles. [PDF]

Epigenomics
Roth C, Venu V, Bacot S, Starkenburg SR, Steadman CR.   +4 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, Volume 20, Issue 3, Page 637-667, March 2026.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DNA methylation-based health predictors: advances, applications, and perspectives. [PDF]

Epigenomics
Xu Z.
europepmc   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Introduction to a Special Issue Describing an Observational Cohort of Adults With Chronic Low Back Pain. [PDF]

JOR Spine
Vo NV, Sowa GA.
europepmc   +1 more source

ALKBH5-mediated m6A demethylation of TXNDC5 drives malignant progression in gastric cancer. [PDF]

Epigenomics
Peng W, Wei X, Zhou F, Xu H.
europepmc   +1 more source

Multiomics Data Synthesis of FAM83H in Amelogenesis Imperfecta. [PDF]

Int Dent J
Leban T, Kunej T.
europepmc   +1 more source