Results 141 to 150 of about 53,444 (288)

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention

Precision Medical Sciences, EarlyView.
This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai, Mosi Chen, Jun Hu, Lei Huang, Ye Yang, Chang Chen, Ying Zhuang, Yan Pan, Bingjun Qian   +8 more
wiley   +1 more source

Publisher Correction: Epigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer

Scientific Reports, 2023
Aida Bao-Caamano, Nicolás Costa-Fraga, Laure Cayrefourcq, María Amalia Jácome, Aitor Rodriguez-Casanova, Laura Muinelo-Romay, Rafael López-López, Catherine Alix-Panabières, Angel Díaz-Lagares   +8 more
doaj   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

DNA methylation and epigenomic profiling post‐mortem of human remain analogs (Sus scrofa) in southern Ontario, Canada

Journal of Forensic Sciences, EarlyView.
Abstract Understanding the dynamics of DNA methylation (DNAm) post‐mortem could support forensic applications, particularly the estimation of the post‐mortem interval (PMI), age, and sex of remains. In this study, we investigated DNAm changes in pig carcasses (Sus scrofa) as analogs for human decomposition, while measuring the progression of decay ...
Irina Badell, Lesley Hewett, Theresa Stotesbury, Shari Forbes, Aaron B. A. Shafer   +4 more
wiley   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Editorial: Insights in genetics, genomics and epigenomics of aging: 2025. [PDF]

Front Aging
Reale M.
europepmc   +1 more source

Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms

Allergy, EarlyView.
ABSTRACT Background Atopic diseases—including atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma—are the most common chronic conditions in childhood and adolescence, affecting up to 30% of the global population. In Germany alone, more than 2.1 million children and adolescents are affected.
E. Hamelmann, B. Schaub, K. Beyer, K. Blümchen, M. Gerstlauer, M. V. Kopp, L. Lange, S. Lau, N. Maison, H. Ott, S. M. Schmidt, T. Spindler, C. Traidl‐Hoffmann, C. Vogelberg   +13 more
wiley   +1 more source

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Multiomics for Risk Stratification in Atherosclerotic Cardiovascular Disease. [PDF]

Circ Genom Precis Med
Nordestgaard LT, Magni P, Sopić M, Chemaly M, Matic L, Dalila N, Trindade F, Wolford BN, Rodriguez-Hernandez Z, Amigó N, Catapano AL, Masana L, Devaux Y.   +12 more
europepmc   +1 more source