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Introduction to Epigenomics and Epigenome-Wide Analysis
2009Epigenetics is the study of heritable change other than those encoded in DNA sequence. Cytosine methylation of DNA at CpG dinucleotides is the most well-studied epigenetic phenomenon, although epigenetic changes also encompass non-DNA methylation mechanisms, such as covalent histone modifications, micro-RNA interactions, and chromatin remodeling ...
Melissa J, Fazzari, John M, Greally
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Critical Reviews in Food Science and Nutrition, 2015
The epigenetic phenomena refer to heritable changes in gene expression other than those in the DNA sequence, such as DNA methylation and histone modifications. Major research progress in the last few years has provided further proof that environmental factors, including diet and nutrition, can influence physiologic and pathologic processes through ...
Shimrit, Bar-El Dadon, Ram, Reifen
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The epigenetic phenomena refer to heritable changes in gene expression other than those in the DNA sequence, such as DNA methylation and histone modifications. Major research progress in the last few years has provided further proof that environmental factors, including diet and nutrition, can influence physiologic and pathologic processes through ...
Shimrit, Bar-El Dadon, Ram, Reifen
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Human Molecular Genetics, 2013
Epigenetic studies include the investigation of DNA methylation, histone modifications, chromatin remodeling and gene regulation by noncoding RNAs (ncRNAs). Epigenetic alterations are critical for early developmental processes, the silencing of the inactive X-chromosome and tissue-specific gene regulation. A comprehensive picture of epigenetic patterns
Dieter, Weichenhan, Christoph, Plass
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Epigenetic studies include the investigation of DNA methylation, histone modifications, chromatin remodeling and gene regulation by noncoding RNAs (ncRNAs). Epigenetic alterations are critical for early developmental processes, the silencing of the inactive X-chromosome and tissue-specific gene regulation. A comprehensive picture of epigenetic patterns
Dieter, Weichenhan, Christoph, Plass
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Trends in Plant Science, 2008
Recent studies of plant development and environmental stress responses have converged on the roles of RNA and its metabolism as primary regulators of gene action. This RNA-based system appears to represent a versatile platform both for maintaining epigenetic memory and for reprogramming gene control in response to external signals.
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Recent studies of plant development and environmental stress responses have converged on the roles of RNA and its metabolism as primary regulators of gene action. This RNA-based system appears to represent a versatile platform both for maintaining epigenetic memory and for reprogramming gene control in response to external signals.
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Personalized Medicine, 2006
Earlier diagnosis and a more individualized choice of treatment options has the potential to greatly improve the outcome of life-threatening diseases. DNA methylation has proven to be a rich source of biomarkers for diagnosis, prognosis and drug response prediction in cancer and other diseases.
Christoph, Sachsenmaier, Achim, Plum
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Earlier diagnosis and a more individualized choice of treatment options has the potential to greatly improve the outcome of life-threatening diseases. DNA methylation has proven to be a rich source of biomarkers for diagnosis, prognosis and drug response prediction in cancer and other diseases.
Christoph, Sachsenmaier, Achim, Plum
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2010
Cancer is a heterogeneous disease caused largely by abnormalities of the genome and the epigenome. Typically, such abnormalities include genetic changes such as mutations and other genomic rearrangements or epigenetic changes such as aberrant DNA methylation and histone modifications that are frequently mediated by exposure to environmental or ...
Matthias, Lechner +2 more
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Cancer is a heterogeneous disease caused largely by abnormalities of the genome and the epigenome. Typically, such abnormalities include genetic changes such as mutations and other genomic rearrangements or epigenetic changes such as aberrant DNA methylation and histone modifications that are frequently mediated by exposure to environmental or ...
Matthias, Lechner +2 more
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Nature Chemical Biology, 2015
Epigenetic chemical probes are having a strong impact in biological discovery and target validation. Systematic coverage of emerging epigenetic target classes with these potent, selective, cell-active chemical tools will profoundly influence understanding of the human biology and pathology of chromatin-templated mechanisms.
Andrea, Huston +3 more
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Epigenetic chemical probes are having a strong impact in biological discovery and target validation. Systematic coverage of emerging epigenetic target classes with these potent, selective, cell-active chemical tools will profoundly influence understanding of the human biology and pathology of chromatin-templated mechanisms.
Andrea, Huston +3 more
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The Concepts of Epigenomics and Cell Epigenomes
2023Genetics cannot solely explain genetic variations in humans and disease developments. We see varying differences in phenotypes and disease susceptibility in organisms that have the same genetic make-up, e.g., monozygotic twins and cloned animals.
Daştan, Taner, Baral, İnanç
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Communications of the ACM, 2023
Computer power helps biologists track the regulation of genetic information.
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Computer power helps biologists track the regulation of genetic information.
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2012
Epigenetic regulation is central to genome structure and function. Epigenetic status varies between individuals, and there is increasing awareness of the importance of this variation in health and disease. Epigenetic mechanisms include DNA methylation, histone modification, and regulation by noncoding RNAs.
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Epigenetic regulation is central to genome structure and function. Epigenetic status varies between individuals, and there is increasing awareness of the importance of this variation in health and disease. Epigenetic mechanisms include DNA methylation, histone modification, and regulation by noncoding RNAs.
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