Results 251 to 260 of about 33,317 (303)
Abstract Single‐cell multi‐omics sequencing technology provides a powerful tool for studying cellular heterogeneity. However, beyond the challenges of sparsity, heterogeneity, and dimensionality differences, a critical challenge in multi‐omics data integration lies in preserving the true regulatory relationships among molecular features.
Yucheng Lu, Xun Zhang, Hongwei Li
wiley +1 more source
Multi-omics strategies for biomarker discovery and application in personalized oncology. [PDF]
Jiang Z, Zhang H, Gao Y, Sun Y.
europepmc +1 more source
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon +5 more
wiley +1 more source
Twenty-five years of briefings in bioinformatics. [PDF]
Bishop M.
europepmc +1 more source
Integrative multi-omics profiling for early diagnosis, stratification and personalized management of chronic kidney disease: a new paradigm. [PDF]
Li Y +3 more
europepmc +1 more source
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Multi-omics-driven biomarker discovery in autoimmune diseases: a comprehensive review. [PDF]
Zhang Y +5 more
europepmc +1 more source
Science of omics: a molecular space odyssey
Experimental Physiology, EarlyView.
Salomé Coppens +3 more
wiley +1 more source
Correction: Commentary: RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations. [PDF]
Yin L.
europepmc +1 more source

