Results 251 to 260 of about 43,487 (351)

Time for the epigenome [PDF]

Nature, 2010
openaire   +2 more sources

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

Cell Proliferation, EarlyView.
Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen   +13 more
wiley   +1 more source

Genome-Wide Impact of Folic Acid on DNA Methylation and Gene Expression in Lupus Adipocytes: An In Vitro Study on Obesity. [PDF]

Nutrients
Souza LL, da Mota JCNL, Carvalho LM, Ribeiro AA, Caponi CA, Pinhel MAS, Costa-Fraga N, Diaz-Lagares A, Izquierdo AG, Nonino CB, Crujeiras AB, Nicoletti CF.   +11 more
europepmc   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Epigenetic Aging Acceleration in Obesity Is Slowed Down by Nutritional Ketosis Following Very Low-Calorie Ketogenic Diet (VLCKD): A New Perspective to Reverse Biological Age. [PDF]

Nutrients
Izquierdo AG, Lorenzo PM, Costa-Fraga N, Primo-Martin D, Rodriguez-Carnero G, Nicoletti CF, Martínez JA, Casanueva FF, de Luis D, Diaz-Lagares A, Crujeiras AB.   +10 more
europepmc   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

Illuminating diabetes <i>via</i> multi-omics: Unraveling disease mechanisms and advancing personalized therapy. [PDF]

World J Diabetes
Song CM, Lin TH, Huang HT, Yao JY.
europepmc   +1 more source

Genetic alterations in hepatocellular carcinoma after sustained virological response in relation to the molecular characterization of metabolic diseases

Hepatology Research, EarlyView.
Hepatocellular carcinoma (HCC) in the hepatitis C virus (HCV)‐sustained virologic response (SVR) group was associated with alcohol consumption and metabolic diseases and showed significantly lower rates of ARID2 alterations and AXIN1 alterations compared to the HCV‐non‐SVR group, with a mutational profile resembling that of the steatotic liver disease ...
Fukiko Kawai‐Kitahata, Yasuhiro Asahina, Sei Kakinuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Tsubasa Nobusawa, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Yuko Kinowaki, Daisuke Ban, Shinji Tanaka, Tatsuhiko Anzai, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Ryuichi Okamoto   +21 more
wiley   +1 more source

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source

Comparative analysis of statistical and deep learning-based multi-omics integration for breast cancer subtype classification. [PDF]

J Transl Med
Omran MM, Emam M, Gamaleldin M, Abushady AM, Elattar MA, El-Hadidi M.   +5 more
europepmc   +1 more source