International Journal of Laboratory Hematology, EarlyView.ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley +1 more source
Multi-omics analysis of the tumor microenvironment after metastasis: advancing toward personalized immunotherapy and molecular targeted strategies. [PDF]
Front ImmunolGao Q, Wu H, Duan L, Lv G, Quan D.
europepmc +1 more source
Exhaustion‐Resistant CD8+ T Cells in Ankylosing Spondylitis: A Proposed Three‐Axis Model
Immunology, EarlyView.Exhaustion‐resistant CD8+ T cells may sustain ankylosing spondylitis. A three‐axis model—intermittent T‐cell receptor engagement, IL‐15/CD28 co‐stimulation and maintained metabolic fitness—explains how PD‐1^high CD8+ T cells retain effector function and accumulate from gut to entheses, promoting inflammation and aberrant bone remodelling.
Xuhong Zhang +3 more
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Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path. [PDF]
Cell GenomGiraud Collet G, Festuccia N, Navarro P.
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Rewiring the stomatal lineage: A novel developmental pathway to plant totipotency
Journal of Integrative Plant Biology, EarlyView.This commentary highlights a study revealing that stomatal lineage precursor cells can be reprogrammed into somatic embryos through a LEC2–SPCH–YUC auxin regulatory circuit. This study uncovers a developmental route to plant totipotency and offers promising strategies for improving regeneration efficiency in difficult‐to‐transform crop species.
Kang Chong
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Towards a Multi-omics Understanding of Anaphylaxis: Insights into Pathogenesis and Biomarker Identification. [PDF]
Clin Rev Allergy ImmunolSvetina M +3 more
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Epigenetic Regulation in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch +3 more
wiley +1 more source
The Identification of Novel Therapeutic Biomarkers in Rheumatoid Arthritis: A Combined Bioinformatics and Integrated Multi-Omics Approach. [PDF]
Int J Mol SciTariq MH +7 more
europepmc +1 more source