Results 261 to 270 of about 55,460 (328)

Epigenetic Mechanisms in Childhood Obesity

Annals of the New York Academy of Sciences, EarlyView.
Abstract Epigenetic mechanisms, including DNA methylation, histone modification, and activity of noncoding RNAs (nc RNAs), affect the regulation of gene expression. These mechanisms are regulated by numerous environmental factors and are critical at specific windows of biological development, when organs and systems plasticity is increased.
Guadalupe León‐Reyes, Génesis K. González‐Quijano, Francisco J. López‐Alavez, Maria Elizabeth Tejero   +3 more
wiley   +1 more source

Multi-omics based and AI-driven drug repositioning for epigenetic therapy in female malignancies. [PDF]

J Transl Med
Salvati A, Melone V, Giordano A, Lamberti J, Palumbo D, Palo L, Rea D, Memoli D, Simonis V, Alexandrova E, Silvestro F, Rizzo F, Weisz A, Tarallo R, Nassa G.   +14 more
europepmc   +1 more source

Renato Dulbecco: genes, cancer and epigenomics

, 2012
Ileana Zucchi
openalex   +2 more sources

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

The role of multi-omics in biomarker discovery, diagnosis, prognosis, and therapeutic monitoring of tissue repair and regeneration processes. [PDF]

J Orthop Translat
Liu J, Yang L, Liu D, Wu Q, Yu Y, Huang X, Li J, Liu S.   +7 more
europepmc   +1 more source

The Epigenetic Regulation of Agronomic Traits and Environmental Adaptability in Brassicas

Plant, Cell &Environment, EarlyView.
ABSTRACT As essential sources of vegetables, oilseeds, and forage, Brassica crops exhibit complex epigenetic regulation mechanisms involving histone modifications, DNA modifications, RNA modifications, noncoding RNAs, and chromatin remodelling. The agronomic traits and environmental adaptability of crops are regulated by both genetic and epigenetic ...
Daolei Zhang, Yin Lu, Wei Ma, Jianjun Zhao   +3 more
wiley   +1 more source

Beyond Biomarkers: Machine Learning-Driven Multiomics for Personalized Medicine in Gastric Cancer. [PDF]

J Pers Med
Ma D, Fan C, Sano T, Kawabata K, Nishikubo H, Imanishi D, Sakuma T, Maruo K, Yamamoto Y, Matsuoka T, Yashiro M.   +10 more
europepmc   +1 more source

Bivalent Histone Modifications Orchestrate Temporal Regulation of Glucosinolate Biosynthesis During Wound‐Induced Stress Responses in Arabidopsis

Plant, Cell &Environment, EarlyView.
ABSTRACT Glucosinolates (GSLs) are secondary metabolites central to plant defence in the Brassicaceae family. While the role of histone modifications in developmental gene regulation is well studied, their function in stress‐induced secondary metabolism remains unclear.
Dasom Choi, Sang Woo Lee, Dong‐Hwan Kim   +2 more
wiley   +1 more source

Advancing omics technologies in acute respiratory distress syndrome: paving the way for personalized medicine. [PDF]

Intensive Care Med Exp
Al-Husinat L, Araydah M, Al Sharie S, Azzam S, Battaglini D, Alrababah A, Haddad R, Al-Asad K, Dos Santos CC, Schultz MJ, Cruz FF, Silva PL, Rocco PRM.   +12 more
europepmc   +1 more source

A dynamic epigenetic perspective on above‐ and belowground phenotypic responses to drought: Insights from global DNA methylation in Erodium cicutarium

Plant Biology, EarlyView.
Our factorial experimental design investigates the relationships between DNA methylation, plant development and individual fitness under stress in Erodium cicutarium. We found that epigenetic modifications associated to 5‐azacytidine seed treatment desynchronized plant growth and delayed flowering.
C. Alonso, M. Medrano, C. M. Herrera
wiley   +1 more source