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Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy
Neurology Clinical Practice, 2023Cenobamate (CNB) is a United States Food and Drug Administration-approved antiseizure medication (ASM) for focal-onset seizures; however, its potential clinical effectiveness as a broad-spectrum ASM is not established. CNB has a proposed dual mechanism of action with preferential blockade of persistent sodium currents and positive allosteric modulation
Shruti Agashe +8 more
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2019
Idiopathic generalized epilepsies (IGE) are characterized by normal background EEG activity and generalized interictal spike-and-wave discharges in the absence of any evidence of brain lesion. Absence epilepsies are the prototypes of IGEs. In childhood and juvenile absence epilepsies, by definition, all patients manifest absence seizures associated ...
Guerrini R., Marini C., Barba C.
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Idiopathic generalized epilepsies (IGE) are characterized by normal background EEG activity and generalized interictal spike-and-wave discharges in the absence of any evidence of brain lesion. Absence epilepsies are the prototypes of IGEs. In childhood and juvenile absence epilepsies, by definition, all patients manifest absence seizures associated ...
Guerrini R., Marini C., Barba C.
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Idiopathic generalized epilepsies
2012Abstract The idiopathic generalized epilepsies (IGEs) are a spectrum of epilepsy syndromes that are characterized by seizures of generalized onset, and by known or presumed genetic etiology. These syndromes occur frequently in adults and children aged above 2 years.
Amy, Kao, Pooja M, Rao
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Idiopathic generalized epilepsies
2013Idiopathic generalized epilepsies (IGEs) may start in infancy, childhood, or adolescence, but some have an onset in adulthood. They are genetically determined and affect otherwise healthy people of both sexes and all races, and are generally lifelong. Some, however, are age related. IGEs account for nearly a third of all epilepsies.
Roberto H, Caraballo +1 more
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Photosensitivity in generalized epilepsies
Epilepsy & Behavior, 2017Photosensitivity, which is the hallmark of photosensitive epilepsy (PSE), is described as an abnormal EEG response to visual stimuli known as a photoparoxysmal response (PPR). The PPR is a well-recognized phenomenon, occurring in 2-14% of patients with epilepsy but its pathophysiology is not clearly understood.
Shervonne, Poleon, Jerzy P, Szaflarski
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Idiopathic Generalized Epilepsies Imitating Focal Epilepsies
Epilepsia, 2005Summary: Classification of epileptic seizures and epilepsy syndromes as either focal or generalized is a fundamental and early part in the diagnostic process and is generally fairly easily accomplished. However, in patients with idiopathic generalized epilepsies, seizure and EEG features may suggest, particularly to the unwary, the occurrence of focal
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GENERALIZED HYPERHIDROSIS FOLLOWING EPILEPSY
British Journal of Dermatology, 1971SUMMARY.— A case is reported of the sudden development in an elderly woman of severe generalized hyperhidrosis, precipitated by heat, emotion and the ingestion of warm drinks. The abnormal sweating followed within a few days of the onset of epilepsy, and it is suggested that the hyperhidrosis may have followed a small cerebrovascular accident in the ...
W J, Cunliffe, C E, Johnson, J L, Burton
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Symptomatic Epilepsies Imitating Idiopathic Generalized Epilepsies
Epilepsia, 2005Summary: The diagnosis of idiopathic generalized epilepsies (IGEs) is not generally difficult if one follows the clinical and electroencephalogram (EEG) definitions of each subsyndrome that constitutes IGEs. In contrast, symptomatic epilepsies develop based on organic brain lesions and are easily diagnosed by the presence of developmental delay ...
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Pre- and post-dormitum epilepsies: Idiopathic generalized epilepsies
Sleep Medicine, 2011Epilepsy and sleep have a profound bidirectional influence. Idiopathic generalized epilepsy (IGE) comprises a fascinating group of syndromes that constitute nearly one-third of all epilepsies. These syndromes are genetically determined and affect otherwise normal people of both sexes and all races.
E. Zambrelli, M.P. Canevini
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Feline generalized penicillin epilepsy
The Italian Journal of Neurological Sciences, 1995Feline generalized penicillin epilepsy represents an experimental model of generalized spike-and-wave discharges occurring during clinical absence attacks. Spike-and-wave discharges of feline generalized penicillin epilepsy also have a pharmacological profile that is similar to that encountered in human absence attacks.
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