Results 31 to 40 of about 8,953 (240)

Synthesis of Two Epimers of Pseudopaline [PDF]

European Journal of Organic Chemistry, 2020
Opines are a known group of compounds characterized by an elevated polarity. Recently, two new members of this class, staphylopine and pseudopaline, have been identified in Staphylococcus aureus and Pseudomonas aeruginosa, respectively. These molecules are metal chelators that contribute to the growth of bacteria in particularly metal‐poor environment.
Cullia, Gregorio, Fanelli, Roberto, Voulhoux, Romé, Arnoux, Pascal, Cavelier, Florine   +4 more
openaire   +1 more source

Studies on the Diels-Alder adduct from cyclopentadiene and p-benzoquinone: Biotransformation, enantiomeric excess and absolute configuration

Orbital: The Electronic Journal of Chemistry, 2012
The use of microorganisms or isolated enzymes in synthetic routes has been extensively used by industry and academic research. A great advantage of biotransformation in a synthetic route is highly regio- and enatiosselective control, which can be ...
Felipe Camargo Braga, Dênis P. de Lima, Adilson Beatriz, Felicia M. Ito   +3 more
doaj   +1 more source

The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3′,4′-di-deoxygenation via reduction and transamination activities

Microbial Cell Factories, 2020
Background New semi-synthetic aminoglycoside antibiotics generally use chemical modifications to avoid inactivity from pathogens. One of the most used modifications is 3′,4′-di-deoxygenation, which imitates the structure of gentamicin.
Xiaotang Chen, Hui Zhang, Shaotong Zhou, Mingjun Bi, Shizhou Qi, Huiyuan Gao, Xianpu Ni, Huanzhang Xia   +7 more
doaj   +1 more source

Distinguishing Epimers Through Raman Optical Activity [PDF]

The Journal of Physical Chemistry A, 2016
The Raman optical activity spectra of the epimers β-D-glucose and β-D-galactose, two monosaccharides of biological importance, have been calculated using molecular dynamics combined with a quantum mechanics/molecular mechanics approach. Good agreement between theoretical and experimental spectra is observed for both monosaccharides.
Mutter, Shaun, Zielinski, Francois, Johannessen, Christian, Popelier, Paul; id_orcid 0000-0001-9053-1363, Blanch, Ewan W.   +4 more
openaire   +5 more sources

epimers

, 2014
Citation: 'epimers' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E02167 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire   +1 more source

1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor.

PLoS ONE, 2011
BackgroundThe 1α,25-dihydroxy-3-epi-vitamin-D3 (1α,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription ...
Ferdinand Molnár, Rita Sigüeiro, Yoshiteru Sato, Clarisse Araujo, Inge Schuster, Pierre Antony, Jean Peluso, Christian Muller, Antonio Mouriño, Dino Moras, Natacha Rochel   +10 more
doaj   +1 more source

Biotransformation of docosahexaenoic acid into 10R,17S- dihydroxydocosahexaenoic acid as protectin Dx 10-epimer by serial reactions of arachidonate 8R- and 15S-lipoxygenases [PDF]

, 2023
Tae‐Eui Lee, Yoon‐Joo Ko, Kyung‐Chul Shin, Deok‐Kun Oh   +3 more
openalex   +1 more source

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide

Molecules, 2000
Goyazensolide, a biologically active natural product classified as a furoheliangolide, was transformed in a phthalimide derivative that showed an enhanced biological activity against Tripanosoma cruzi.
Mauricio Gomes Constantino, Vladimir Constantino Gomes Heleno, Gil Valdo José da Silva   +2 more
doaj   +1 more source

FLP Mediated Conversion of Difluorobenzylalkynes to Fluoroallenyl Oniums via an SN1’ Pathway

Chemistry – A European Journal, EarlyView.
Frustrated Lewis pair (FLP) selective C‒F activation of difluorobenzylalkynes allows the formation of fluoroallenic oniums via an SN1’ substitution pathway. The fluoroallenic onium salts are synthetic precursors that allow subsequent functionalization at allenic and onium positions.
Max Coles, Tianhong Wang, Rubi McLennan, Long Kit Kwan, Bivas Mondal, Chakyu Richard Chan, Rowan D. Young   +6 more
wiley   +1 more source